Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 1668141..1668788 Replicon chromosome
Accession NZ_LT549890
Organism Saccharolobus solfataricus strain P1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SSOP1_RS08900 Protein ID WP_009990357.1
Coordinates 1668141..1668413 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E3K976
Locus tag SSOP1_RS08905 Protein ID WP_009990356.1
Coordinates 1668528..1668788 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSOP1_RS08885 (SSOP1_1867) 1663402..1664453 - 1052 Protein_1778 ISH3 family transposase -
SSOP1_RS08895 (SSOP1_1870) 1666671..1667618 - 948 WP_009990359.1 ATP/GTP-binding protein -
SSOP1_RS08900 (SSOP1_1871) 1668141..1668413 - 273 WP_009990357.1 PIN domain-containing protein Toxin
SSOP1_RS08905 (SSOP1_1872) 1668528..1668788 - 261 WP_009990356.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SSOP1_RS08910 (SSOP1_1873) 1669059..1670024 - 966 WP_010923029.1 ISH3-like element ISC1439A family transposase -
SSOP1_RS17095 1670923..1671084 + 162 WP_009990355.1 hypothetical protein -
SSOP1_RS08920 (SSOP1_1874) 1671186..1671644 + 459 WP_009990354.1 hypothetical protein -
SSOP1_RS08925 (SSOP1_1875) 1672393..1672899 - 507 WP_014511696.1 thiosulfate:quinone oxidoreductase small subunit -
SSOP1_RS08930 (SSOP1_1876) 1672905..1673447 - 543 WP_009990352.1 thiosulfate:quinone oxidoreductase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1660998..1678149 17151
- inside IScluster/Tn - - 1660998..1678702 17704


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(20-82)

Antitoxin

SpoVT-AbrB domain

(7-46)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10475.34 Da        Isoelectric Point: 9.7534

>T293128 WP_009990357.1 NZ_LT549890:c1668413-1668141 [Saccharolobus solfataricus]
MRLFTLSKKKYNVKFEDTIDFLDKIILPYTIILPINSHDYEKAKGIMISKTLKPSDAFHVAVMINNSIKKIVSEDSDFDK
INGIERIWVK

Download         Length: 273 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9842.51 Da        Isoelectric Point: 5.2456

>AT293128 WP_009990356.1 NZ_LT549890:c1668788-1668528 [Saccharolobus solfataricus]
MTLKIEVGKKGYIIIPKTVRDLLEIKEGDILILRVEDGKIVLEPERKVSFDDLKKKMEEHSAKISYANKAKLGDLINVSL
EEEFDN

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E3K976

References