Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 1432611..1433211 Replicon chromosome
Accession NZ_LT549890
Organism Saccharolobus solfataricus strain P1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SSOP1_RS07775 Protein ID WP_048054229.1
Coordinates 1432822..1433211 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A157T1M9
Locus tag SSOP1_RS07770 Protein ID WP_048054328.1
Coordinates 1432611..1432835 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSOP1_RS07745 (SSOP1_1600) 1428679..1429122 - 444 WP_010923418.1 hypothetical protein -
SSOP1_RS07750 (SSOP1_1601) 1429206..1429634 - 429 WP_010923419.1 transposase -
SSOP1_RS17635 1429702..1429872 + 171 Protein_1545 transposase -
SSOP1_RS07755 (SSOP1_1602) 1429847..1430743 - 897 Protein_1546 ISH3-like element ISC1225 family transposase -
SSOP1_RS07760 (SSOP1_1603) 1430916..1431875 - 960 WP_010923364.1 IS5-like element ISC1234 family transposase -
SSOP1_RS07765 (SSOP1_1604) 1431973..1432137 - 165 Protein_1548 DUF4322 domain-containing protein -
SSOP1_RS07770 (SSOP1_1605) 1432611..1432835 + 225 WP_048054328.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SSOP1_RS07775 (SSOP1_1606) 1432822..1433211 + 390 WP_048054229.1 PIN domain-containing protein Toxin
SSOP1_RS17005 1433652..1433819 - 168 WP_158011701.1 hypothetical protein -
SSOP1_RS17010 (SSOP1_1608) 1433902..1434366 - 465 WP_231918247.1 hypothetical protein -
SSOP1_RS07790 (SSOP1_1609) 1434506..1435771 - 1266 WP_010923438.1 MFS transporter -
SSOP1_RS07795 (SSOP1_1610) 1436818..1437993 + 1176 WP_010923437.1 RNA-guided endonuclease TnpB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 1425258..1437993 12735


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin

SpoVT-AbrB domain

(4-45)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14446.03 Da        Isoelectric Point: 4.5625

>T293126 WP_048054229.1 NZ_LT549890:1432822-1433211 [Saccharolobus solfataricus]
MIVVDTNVLIYATLEDSEFHTQSLEIIEGSDIIVPQIVVFEYIKVLSEIVQNLDFIKTKISELNNFVVVCEDLNTIALAL
RLLAELKLSLKDINDMIILTAAIKTNSSIATFDQKLRKIADKKGVKVLP

Download         Length: 390 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8530.93 Da        Isoelectric Point: 8.5049

>AT293126 WP_048054328.1 NZ_LT549890:1432611-1432835 [Saccharolobus solfataricus]
MISKVTRNFQVTIPYEIRKVLGIKEGDYIEFAIENGKVMIKPVRKVWSTIRLGREVTVEEIEEIASKAFKDDSS

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A157T1M9

References