Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2751477..2752039 Replicon chromosome
Accession NZ_LT220504
Organism Lacticaseibacillus rhamnosus strain BPL5

Toxin (Protein)


Gene name mazF Uniprot ID C2JYM4
Locus tag BN3853_RS12910 Protein ID WP_005692155.1
Coordinates 2751692..2752039 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag BN3853_RS12905 Protein ID WP_014571589.1
Coordinates 2751477..2751692 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN3853_RS12895 2747768..2749558 + 1791 WP_061713737.1 ABC transporter ATP-binding protein/permease -
BN3853_RS12900 2749545..2751380 + 1836 WP_015764721.1 ABC transporter ATP-binding protein/permease -
BN3853_RS12905 2751477..2751692 + 216 WP_014571589.1 hypothetical protein Antitoxin
BN3853_RS12910 2751692..2752039 + 348 WP_005692155.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BN3853_RS15205 2752562..2752705 - 144 WP_015764720.1 hypothetical protein -
BN3853_RS12915 2752885..2753553 + 669 WP_005692157.1 tRNA ligase -
BN3853_RS12920 2753794..2754612 + 819 WP_014571588.1 ABC transporter permease subunit -
BN3853_RS12925 2754605..2755306 + 702 WP_005692159.1 ABC transporter ATP-binding protein -
BN3853_RS12930 2755303..2756544 + 1242 WP_005692160.1 acyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13150.01 Da        Isoelectric Point: 7.9817

>T293117 WP_005692155.1 NZ_LT220504:2751692-2752039 [Lacticaseibacillus rhamnosus]
MTYKAKQGDVVWLDFDPSEGHEIRKRCPAVVLSSNAYNRATGFVIVAPITSTIRTLPGYVDIVSNKIRGQVVTSQVYSLD
VTEQGNRKIDFIERMNIEDFYTVAQFTKMNFDFKF

Download         Length: 348 bp

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7986.13 Da        Isoelectric Point: 5.7995

>AT293117 WP_014571589.1 NZ_LT220504:2751477-2751692 [Lacticaseibacillus rhamnosus]
MDVKVVKRGNSLALSLPSSAGFKRGEAFLLISDEKGGYLLIPKVKNPYTKAKPLSFHQEEAWPDFDYEDIE

Download         Length: 216 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z9DS75

Antitoxin

Source ID Structure

References