Detailed information of TA system TA029311

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/Txe-RelB
• Location: 451408..451937
• Replicon: chromosome
• Accession: NC_020995
• Organism: Enterococcus casseliflavus EC20

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C9AA02
• Locus tag: ECBG_RS02130
• Protein ID: WP_015508898.1
• Coordinates: 451671..451937 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: C9AA01
• Locus tag: ECBG_RS02125
• Protein ID: WP_015508897.1
• Coordinates: 451408..451671 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECBG_RS02110	446980..448242	-	1263	WP_015508894.1	glycoside hydrolase family 27 protein	-
ECBG_RS02115	448363..449262	+	900	WP_015508895.1	AraC family transcriptional regulator	-
ECBG_RS02120	449313..451253	+	1941	WP_015508896.1	glycoside hydrolase family 127 protein	-
ECBG_RS02125	451408..451671	+	264	WP_015508897.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
ECBG_RS02130	451671..451937	+	267	WP_015508898.1	Txe/YoeB family addiction module toxin	Toxin
ECBG_RS02135	452130..454961	+	2832	WP_015508899.1	discoidin domain-containing protein	-
ECBG_RS02140	455093..455746	-	654	WP_170920125.1	ABC transporter permease	-
ECBG_RS02145	455760..456680	-	921	WP_010748740.1	osmoprotectant ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (5-69)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10584.13 Da
• Isoelectric Point: 10.3674

>T29311 WP_015508898.1 NC_020995:451671-451937 [Enterococcus casseliflavus EC20]
MRSDTVTIKNSAKVDLRKIKQSNLKKQFEEVIQALKEAPYMPTQFFEKLRPAHEGRYSRRLSRQHRVVYKVNEENKVVEI
YSGWTHYE

Nucleotide

• Length: 267 bp

>T29311 NC_020995:451671-451937 [Enterococcus casseliflavus EC20]
ATGAGGAGCGATACGGTCACAATCAAAAACTCTGCGAAAGTGGATCTAAGGAAAATCAAACAATCGAATTTAAAAAAACA
GTTTGAAGAAGTGATTCAGGCCTTGAAGGAAGCTCCATATATGCCCACGCAGTTTTTTGAAAAGCTGAGACCTGCACATG
AAGGCAGATATTCACGTAGGCTGAGTAGGCAACATCGAGTGGTTTACAAAGTTAATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGGATGGACACATTATGAATGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9885.97 Da
• Isoelectric Point: 4.3402

>AT29311 WP_015508897.1 NC_020995:451408-451671 [Enterococcus casseliflavus EC20]
MAKTTMNPSTARKNFYQLLKDVNGNHTEIEIISDRSGNNAVLIGLGDWRAIQETLFLEQTGTLEKVRDREKDDSGFTDID
DIDWQAL

Nucleotide

• Length: 264 bp

>AT29311 NC_020995:451408-451671 [Enterococcus casseliflavus EC20]
ATGGCTAAAACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGATGTAAATGGAAACCATAC
TGAAATTGAGATTATTAGTGATCGAAGTGGAAACAATGCGGTGTTGATTGGGCTAGGAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTCTAGAAAAGGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGGATATCGAT
GATATTGATTGGCAAGCTCTTTGA

Structures

Toxin

• AlphaFold DB: C9AA02

Antitoxin

• AlphaFold DB: C9AA01