Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2172546..2173060 Replicon chromosome
Accession NZ_LT009690
Organism Staphylococcus aureus strain NZAK3

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag NZAK3_RS11050 Protein ID WP_000581792.1
Coordinates 2172546..2172755 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag NZAK3_RS11055 Protein ID WP_000138932.1
Coordinates 2172767..2173060 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NZAK3_RS11030 2168054..2169412 - 1359 WP_061713881.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
NZAK3_RS11035 2169427..2170497 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
NZAK3_RS11040 2170815..2172017 + 1203 WP_001109939.1 rod shape-determining protein RodA -
NZAK3_RS11045 2172281..2172418 - 138 WP_000828354.1 hypothetical protein -
NZAK3_RS11050 2172546..2172755 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
NZAK3_RS11055 2172767..2173060 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
NZAK3_RS11060 2173226..2174710 + 1485 WP_000571549.1 cardiolipin synthase -
NZAK3_RS11065 2174738..2175385 + 648 WP_001187630.1 HD domain-containing protein -
NZAK3_RS11075 2176298..2177170 - 873 WP_000725802.1 membrane protein insertase YidC -
NZAK3_RS11080 2177256..2177897 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T293107 WP_000581792.1 NZ_LT009690:c2172755-2172546 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT293107 WP_000138932.1 NZ_LT009690:c2173060-2172767 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References