Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2151287..2151816 Replicon chromosome
Accession NZ_LT009690
Organism Staphylococcus aureus strain NZAK3

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NZAK3_RS10955 Protein ID WP_000621175.1
Coordinates 2151287..2151649 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag NZAK3_RS10960 Protein ID WP_000948331.1
Coordinates 2151646..2151816 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NZAK3_RS10930 2148265..2149035 - 771 WP_001041111.1 RNA polymerase sigma factor SigB -
NZAK3_RS10935 2149010..2149489 - 480 WP_001190829.1 anti-sigma B factor RsbW -
NZAK3_RS10940 2149491..2149817 - 327 WP_001052491.1 anti-sigma factor antagonist -
NZAK3_RS10945 2149936..2150937 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
NZAK3_RS10955 2151287..2151649 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NZAK3_RS10960 2151646..2151816 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NZAK3_RS10965 2151901..2153049 - 1149 WP_001281154.1 alanine racemase -
NZAK3_RS10970 2153115..2153474 - 360 WP_000581197.1 holo-ACP synthase -
NZAK3_RS10975 2153478..2153969 - 492 WP_001205912.1 PH domain-containing protein -
NZAK3_RS10980 2153956..2155539 - 1584 WP_001294626.1 PH domain-containing protein -
NZAK3_RS10985 2155532..2156011 - 480 WP_001287087.1 hypothetical protein -
NZAK3_RS10990 2156219..2156779 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T293106 WP_000621175.1 NZ_LT009690:c2151649-2151287 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT293106 WP_000948331.1 NZ_LT009690:c2151816-2151646 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References