Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1944757..1945533 Replicon chromosome
Accession NZ_LT009690
Organism Staphylococcus aureus strain NZAK3

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag NZAK3_RS09695 Protein ID WP_000031108.1
Coordinates 1944757..1944909 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag NZAK3_RS09700 Protein ID WP_001251224.1
Coordinates 1944934..1945533 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NZAK3_RS09680 1940959..1941780 + 822 WP_000669376.1 RluA family pseudouridine synthase -
NZAK3_RS09685 1942233..1943618 - 1386 WP_000116228.1 class II fumarate hydratase -
NZAK3_RS09690 1943814..1944209 - 396 WP_000901023.1 hypothetical protein -
NZAK3_RS09695 1944757..1944909 - 153 WP_000031108.1 hypothetical protein Toxin
NZAK3_RS09700 1944934..1945533 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
NZAK3_RS09705 1945692..1946162 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NZAK3_RS09710 1946167..1947294 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
NZAK3_RS09715 1947445..1948167 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NZAK3_RS09720 1948160..1949617 - 1458 WP_031875741.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukD / hlgA / selk 1869230..1967977 98747


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T293102 WP_000031108.1 NZ_LT009690:c1944909-1944757 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT293102 WP_001251224.1 NZ_LT009690:c1945533-1944934 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References