Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 833728..834257 Replicon chromosome
Accession NZ_LT009690
Organism Staphylococcus aureus strain NZAK3

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX6
Locus tag NZAK3_RS04045 Protein ID WP_001103939.1
Coordinates 833940..834257 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID X5IY59
Locus tag NZAK3_RS04040 Protein ID WP_001058494.1
Coordinates 833728..833937 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NZAK3_RS04005 830058..830522 + 465 WP_001085183.1 SsrA-binding protein SmpB -
NZAK3_RS04015 831085..832191 - 1107 WP_000149511.1 site-specific integrase -
NZAK3_RS04020 832181..832984 - 804 WP_000358990.1 helix-turn-helix domain-containing protein -
NZAK3_RS04025 833120..833323 + 204 WP_001045296.1 transcriptional regulator -
NZAK3_RS04030 833359..833577 + 219 WP_000163544.1 helix-turn-helix domain-containing protein -
NZAK3_RS04035 833589..833735 + 147 WP_000784885.1 hypothetical protein -
NZAK3_RS04040 833728..833937 + 210 WP_001058494.1 hypothetical protein Antitoxin
NZAK3_RS04045 833940..834257 + 318 WP_001103939.1 DUF1474 family protein Toxin
NZAK3_RS04050 834321..835190 + 870 WP_001002717.1 primase alpha helix C-terminal domain-containing protein -
NZAK3_RS04055 835207..836664 + 1458 WP_000390453.1 virulence-associated E family protein -
NZAK3_RS04060 836965..837327 + 363 WP_001039170.1 hypothetical protein -
NZAK3_RS04065 837329..837613 + 285 WP_000998185.1 hypothetical protein -
NZAK3_RS04070 837610..838251 + 642 WP_001019808.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12547.17 Da        Isoelectric Point: 5.0161

>T293098 WP_001103939.1 NZ_LT009690:833940-834257 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFGELIQKF
HEIEKASSENFGEVSDDAQKLKITE

Download         Length: 318 bp

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8268.31 Da        Isoelectric Point: 4.3718

>AT293098 WP_001058494.1 NZ_LT009690:833728-833937 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNSIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX6

Antitoxin

Source ID Structure
AlphaFold DB X5IY59

References