Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4395551..4396146 Replicon chromosome
Accession NZ_LS999560
Organism Escherichia coli isolate EC-TO143

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag ECTO143_RS21930 Protein ID WP_000239579.1
Coordinates 4395551..4395901 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag ECTO143_RS21935 Protein ID WP_001223208.1
Coordinates 4395895..4396146 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO143_RS21910 4390997..4392019 - 1023 WP_001296689.1 ABC transporter permease -
ECTO143_RS21915 4392033..4393535 - 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
ECTO143_RS21920 4393675..4394631 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
ECTO143_RS21925 4394941..4395471 + 531 WP_000055075.1 inorganic diphosphatase -
ECTO143_RS21930 4395551..4395901 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
ECTO143_RS21935 4395895..4396146 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
ECTO143_RS21940 4396358..4396699 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
ECTO143_RS21945 4396702..4400481 - 3780 WP_000060945.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T293079 WP_000239579.1 NZ_LS999560:c4395901-4395551 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT293079 WP_001223208.1 NZ_LS999560:c4396146-4395895 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References