Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1926955..1928591 Replicon chromosome
Accession NZ_LS999521
Organism Acinetobacter calcoaceticus isolate Acinetobacter calcoaceticus str. 2117

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag AC2117_RS09240 Protein ID WP_133973575.1
Coordinates 1926955..1928286 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag AC2117_RS09245 Protein ID WP_005040627.1
Coordinates 1928283..1928591 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AC2117_RS09220 1924621..1924785 + 165 Protein_1773 GNAT family N-acetyltransferase -
AC2117_RS09225 1924810..1925445 - 636 WP_133973571.1 3'-5' exonuclease -
AC2117_RS09230 1925576..1925647 + 72 Protein_1775 helix-turn-helix transcriptional regulator -
AC2117_RS09235 1925715..1926710 - 996 WP_133973573.1 putative multidrug efflux protein AdeT1 -
AC2117_RS09240 1926955..1928286 + 1332 WP_133973575.1 type II toxin-antitoxin system HipA family toxin Toxin
AC2117_RS09245 1928283..1928591 + 309 WP_005040627.1 helix-turn-helix domain-containing protein Antitoxin
AC2117_RS09250 1928856..1930154 + 1299 WP_133973577.1 MFS transporter -
AC2117_RS09255 1930230..1930997 + 768 WP_133973579.1 SDR family oxidoreductase -
AC2117_RS09260 1931024..1932106 - 1083 WP_133973581.1 glycerol dehydrogenase -
AC2117_RS09265 1932203..1932751 - 549 WP_080027104.1 2,4'-dihydroxyacetophenone dioxygenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-357)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 51077.11 Da        Isoelectric Point: 5.1434

>T293059 WP_133973575.1 NZ_LS999521:1926955-1928286 [Acinetobacter calcoaceticus]
MKKLTIQALLDKNWVDIADLKLLEPKLGSTSGSELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESNTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYSEQESILLEKGGMAPVGNLRIKEALPPINPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQENFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQVLTELGFNTIETTQM
KLIEGTKYPSLWLPRFDTEWRDQQWHRHGLESVYSVLNKSSGSHLNHFEVINDLCRLLTRIDPDFDAPQFICEWLQRDLL
NIIFGNSDNHGRNTSFLKKSGKISLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLTPWCDPDLSLGTLK
SLAINLLGLKQRLVDKGVPKNIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11504.43 Da        Isoelectric Point: 10.0639

>AT293059 WP_005040627.1 NZ_LS999521:1928283-1928591 [Acinetobacter calcoaceticus]
MNIKNQTQDRQQVLIDLYKQYLLSEITLGQLLSHLRKNVLGLSQEQYAALVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVGKIIKPSE

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References