Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4775941..4776557 Replicon chromosome
Accession NZ_LS999206
Organism Enterobacter hormaechei isolate EC-TO80

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ECLTO80_RS23455 Protein ID WP_017382676.1
Coordinates 4775941..4776312 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag ECLTO80_RS23460 Protein ID WP_015569912.1
Coordinates 4776315..4776557 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECLTO80_RS23440 4773441..4774343 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
ECLTO80_RS23445 4774340..4774975 + 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
ECLTO80_RS23450 4774972..4775901 + 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
ECLTO80_RS23455 4775941..4776312 - 372 WP_017382676.1 type II toxin-antitoxin system VapC family toxin Toxin
ECLTO80_RS23460 4776315..4776557 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
ECLTO80_RS23465 4776756..4777676 + 921 WP_133983330.1 alpha/beta hydrolase -
ECLTO80_RS23470 4777685..4778626 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
ECLTO80_RS23475 4778671..4779108 - 438 WP_015569909.1 D-tyrosyl-tRNA(Tyr) deacylase -
ECLTO80_RS23480 4779105..4779986 - 882 WP_003861949.1 virulence factor BrkB family protein -
ECLTO80_RS23485 4779980..4780579 - 600 WP_133983332.1 glucose-1-phosphatase -
ECLTO80_RS23490 4780698..4781498 - 801 WP_003861944.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13737.88 Da        Isoelectric Point: 6.4882

>T293057 WP_017382676.1 NZ_LS999206:c4776312-4775941 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRIEAADAIEHTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT293057 WP_015569912.1 NZ_LS999206:c4776557-4776315 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References