Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3949955..3950612 Replicon chromosome
Accession NZ_LS999206
Organism Enterobacter hormaechei isolate EC-TO80

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag ECLTO80_RS19385 Protein ID WP_017382887.1
Coordinates 3949955..3950365 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag ECLTO80_RS19390 Protein ID WP_003863437.1
Coordinates 3950346..3950612 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECLTO80_RS19365 3945953..3947686 - 1734 WP_017382886.1 single-stranded-DNA-specific exonuclease RecJ -
ECLTO80_RS19370 3947692..3948405 - 714 WP_033487627.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ECLTO80_RS19375 3948434..3949330 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
ECLTO80_RS19380 3949432..3949953 + 522 WP_015571793.1 flavodoxin FldB -
ECLTO80_RS19385 3949955..3950365 - 411 WP_017382887.1 protein YgfX Toxin
ECLTO80_RS19390 3950346..3950612 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
ECLTO80_RS19395 3950907..3951887 + 981 WP_047636517.1 tRNA-modifying protein YgfZ -
ECLTO80_RS19400 3951999..3952658 - 660 WP_003863433.1 hemolysin III family protein -
ECLTO80_RS19405 3952925..3953656 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
ECLTO80_RS19410 3953773..3955206 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T293056 WP_017382887.1 NZ_LS999206:c3950365-3949955 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT293056 WP_003863437.1 NZ_LS999206:c3950612-3950346 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References