Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 3204927..3206710 Replicon chromosome
Accession NZ_LS999206
Organism Enterobacter hormaechei isolate EC-TO80

Toxin (Protein)


Gene name hipA Uniprot ID A0A2G5A822
Locus tag ECLTO80_RS15810 Protein ID WP_045333653.1
Coordinates 3204927..3206276 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2G5A843
Locus tag ECLTO80_RS15815 Protein ID WP_045333654.1
Coordinates 3206273..3206710 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECLTO80_RS15785 3200750..3201685 - 936 WP_133983007.1 tRNA dihydrouridine(16) synthase DusC -
ECLTO80_RS15790 3201854..3202249 + 396 WP_003859308.1 CidA/LrgA family protein -
ECLTO80_RS15795 3202246..3202941 + 696 WP_015572322.1 CidB/LrgB family autolysis modulator -
ECLTO80_RS15800 3203070..3203954 + 885 WP_133983009.1 cytidine deaminase -
ECLTO80_RS15805 3204082..3204792 + 711 WP_017383381.1 outer membrane permeability protein SanA -
ECLTO80_RS15810 3204927..3206276 + 1350 WP_045333653.1 type II toxin-antitoxin system HipA family toxin Toxin
ECLTO80_RS15815 3206273..3206710 + 438 WP_045333654.1 helix-turn-helix domain-containing protein Antitoxin
ECLTO80_RS15820 3206749..3207759 - 1011 WP_133983011.1 galactose/methyl galactoside ABC transporter permease MglC -
ECLTO80_RS15825 3207775..3209295 - 1521 WP_047365146.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
ECLTO80_RS15830 3209375..3210373 - 999 WP_047365148.1 galactose/glucose ABC transporter substrate-binding protein MglB -
ECLTO80_RS15835 3210669..3211691 - 1023 WP_045341031.1 HTH-type transcriptional regulator GalS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51197.84 Da        Isoelectric Point: 4.6562

>T293054 WP_045333653.1 NZ_LS999206:3204927-3206276 [Enterobacter hormaechei]
METLTVQAYLNETWTDIALIKYPGSEKNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRTLINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNTIAQTLAEWIPPTT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFRYIPDKLSRWGLL

Download         Length: 1350 bp

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16171.61 Da        Isoelectric Point: 10.5154

>AT293054 WP_045333654.1 NZ_LS999206:3206273-3206710 [Enterobacter hormaechei]
MKTPNEAESELLQTLAQVRSVNKKRHHDEAEDPDKPSVVKRQRVTQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADVINKIFKPFGLQTGLVPVSKSLIASLFS

Download         Length: 438 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G5A822

Antitoxin

Source ID Structure
AlphaFold DB A0A2G5A843

References