Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2394489..2395228 Replicon chromosome
Accession NZ_LS999206
Organism Enterobacter hormaechei isolate EC-TO80

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag ECLTO80_RS11855 Protein ID WP_003857133.1
Coordinates 2394489..2394974 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag ECLTO80_RS11860 Protein ID WP_003857131.1
Coordinates 2394962..2395228 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECLTO80_RS11830 2390023..2390607 - 585 WP_017382349.1 GDP-mannose pyrophosphatase nudK -
ECLTO80_RS11835 2390694..2391452 + 759 WP_045341969.1 DeoR/GlpR family DNA-binding transcription regulator -
ECLTO80_RS11840 2391557..2392849 + 1293 WP_133982766.1 glycoside hydrolase -
ECLTO80_RS11845 2393020..2393853 + 834 Protein_2273 hypothetical protein -
ECLTO80_RS11850 2393869..2394438 + 570 WP_017382346.1 hypothetical protein -
ECLTO80_RS11855 2394489..2394974 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
ECLTO80_RS11860 2394962..2395228 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
ECLTO80_RS11865 2395292..2396221 - 930 WP_133982768.1 LysR family transcriptional regulator -
ECLTO80_RS11870 2396351..2397733 + 1383 WP_062938939.1 MFS transporter -
ECLTO80_RS11875 2397756..2398751 - 996 WP_045339807.1 DUF2891 domain-containing protein -
ECLTO80_RS11880 2398761..2399747 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T293047 WP_003857133.1 NZ_LS999206:c2394974-2394489 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT293047 WP_003857131.1 NZ_LS999206:c2395228-2394962 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References