Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) KacT-ataR/DUF1778(antitoxin)
Location 1774493..1775290 Replicon chromosome
Accession NZ_LS999206
Organism Enterobacter hormaechei isolate EC-TO80

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag ECLTO80_RS08655 Protein ID WP_133982579.1
Coordinates 1774769..1775290 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A331QJY7
Locus tag ECLTO80_RS08650 Protein ID WP_015570876.1
Coordinates 1774493..1774762 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECLTO80_RS08615 1770032..1770391 + 360 WP_017384779.1 helix-turn-helix transcriptional regulator -
ECLTO80_RS08620 1770401..1770565 - 165 WP_017693668.1 helix-turn-helix transcriptional regulator -
ECLTO80_RS08625 1770720..1771961 + 1242 WP_017693667.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
ECLTO80_RS08630 1771994..1772221 - 228 WP_006809324.1 YccJ family protein -
ECLTO80_RS08635 1772240..1772836 - 597 WP_006809323.1 NAD(P)H:quinone oxidoreductase -
ECLTO80_RS08640 1773227..1773397 + 171 WP_001273664.1 general stress protein -
ECLTO80_RS08645 1773514..1774419 + 906 WP_032653183.1 DMT family transporter -
ECLTO80_RS08650 1774493..1774762 + 270 WP_015570876.1 DUF1778 domain-containing protein Antitoxin
ECLTO80_RS08655 1774769..1775290 + 522 WP_133982579.1 GNAT family N-acetyltransferase Toxin
ECLTO80_RS08660 1775349..1776671 - 1323 WP_133982581.1 pyrimidine utilization transport protein G -
ECLTO80_RS08665 1776693..1777184 - 492 WP_015570873.1 pyrimidine utilization flavin reductase protein F -
ECLTO80_RS08670 1777197..1777787 - 591 WP_032619952.1 malonic semialdehyde reductase -
ECLTO80_RS08675 1777797..1778597 - 801 WP_126291284.1 pyrimidine utilization protein D -
ECLTO80_RS08680 1778605..1778991 - 387 WP_133982582.1 pyrimidine utilization protein C -
ECLTO80_RS08685 1779003..1779692 - 690 WP_045338811.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(89-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-88)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19479.26 Da        Isoelectric Point: 7.4318

>T293046 WP_133982579.1 NZ_LS999206:1774769-1775290 [Enterobacter hormaechei]
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTEHLIRQHGGRILRGYLLKERDHPRVLGYYTLSGSCFEKVMLPSKTQQR
RIPYSNVPSVTLGRLAVHKELQGNEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQA

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10247.75 Da        Isoelectric Point: 5.8836

>AT293046 WP_015570876.1 NZ_LS999206:1774493-1774762 [Enterobacter hormaechei]
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWIAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A331QJY7

References