Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1150332..1150952 Replicon chromosome
Accession NZ_LS999206
Organism Enterobacter hormaechei isolate EC-TO80

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag ECLTO80_RS05640 Protein ID WP_015571250.1
Coordinates 1150332..1150550 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag ECLTO80_RS05645 Protein ID WP_006809850.1
Coordinates 1150578..1150952 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECLTO80_RS05610 1146344..1146604 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
ECLTO80_RS05615 1146607..1146747 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
ECLTO80_RS05620 1146744..1147454 - 711 WP_023303201.1 GNAT family N-acetyltransferase -
ECLTO80_RS05625 1147556..1149016 + 1461 WP_133982424.1 PLP-dependent aminotransferase family protein -
ECLTO80_RS05630 1148988..1149455 - 468 WP_023296041.1 hypothetical protein -
ECLTO80_RS05635 1149572..1150123 - 552 WP_015571251.1 maltose O-acetyltransferase -
ECLTO80_RS05640 1150332..1150550 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
ECLTO80_RS05645 1150578..1150952 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
ECLTO80_RS05650 1151462..1154608 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit -
ECLTO80_RS05655 1154631..1155824 - 1194 WP_047365350.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T293044 WP_015571250.1 NZ_LS999206:c1150550-1150332 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT293044 WP_006809850.1 NZ_LS999206:c1150952-1150578 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References