Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 684144..684720 Replicon chromosome
Accession NZ_LS999206
Organism Enterobacter hormaechei isolate EC-TO80

Toxin (Protein)


Gene name shpA Uniprot ID A0A800YKM1
Locus tag ECLTO80_RS03445 Protein ID WP_015572580.1
Coordinates 684144..684431 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A801DSF4
Locus tag ECLTO80_RS03450 Protein ID WP_017694570.1
Coordinates 684418..684720 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECLTO80_RS03420 679237..679956 + 720 WP_050515874.1 winged helix-turn-helix domain-containing protein -
ECLTO80_RS03425 680106..680576 + 471 WP_033486706.1 MarR family transcriptional regulator -
ECLTO80_RS03430 680573..681640 + 1068 WP_026080654.1 HlyD family secretion protein -
ECLTO80_RS03435 681630..682706 + 1077 WP_015572578.1 DUF2955 domain-containing protein -
ECLTO80_RS03440 682703..683974 - 1272 WP_033486707.1 DUF445 domain-containing protein -
ECLTO80_RS03445 684144..684431 + 288 WP_015572580.1 BrnT family toxin Toxin
ECLTO80_RS03450 684418..684720 + 303 WP_017694570.1 BrnA antitoxin family protein Antitoxin
ECLTO80_RS03455 684749..685387 - 639 WP_033486708.1 LysE family translocator -
ECLTO80_RS03460 685426..686178 - 753 WP_033486709.1 AraC family transcriptional regulator -
ECLTO80_RS03465 686332..687702 + 1371 WP_133982341.1 NAD-dependent succinate-semialdehyde dehydrogenase -
ECLTO80_RS03470 687884..688429 - 546 WP_006810254.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(32-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11296.81 Da        Isoelectric Point: 7.3587

>T293043 WP_015572580.1 NZ_LS999206:684144-684431 [Enterobacter hormaechei]
MPIEYEWDSNKAKSNLQKHAIRFEDAVLVFDDPCHLSVQDRYENGEFRWQTIGLVQGVIVILVAHTVRFESGDEIIRIIS
ARKADRKERRRYEHR

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11482.13 Da        Isoelectric Point: 10.4094

>AT293043 WP_017694570.1 NZ_LS999206:684418-684720 [Enterobacter hormaechei]
MSIVKHKRGSAPEVSARREAELKALADKPDREIDYSDIPATEDDRWAGAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References