Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 298458..299054 Replicon chromosome
Accession NZ_LS999206
Organism Enterobacter hormaechei isolate EC-TO80

Toxin (Protein)


Gene name PumA Uniprot ID A0A837F9W8
Locus tag ECLTO80_RS01450 Protein ID WP_023315213.1
Coordinates 298752..299054 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag ECLTO80_RS01445 Protein ID WP_032672198.1
Coordinates 298458..298745 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECLTO80_RS01440 296830..298461 + 1632 WP_003860350.1 Na/Pi cotransporter family protein -
ECLTO80_RS01445 298458..298745 - 288 WP_032672198.1 putative addiction module antidote protein Antitoxin
ECLTO80_RS01450 298752..299054 - 303 WP_023315213.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ECLTO80_RS01455 299252..300124 + 873 WP_003860347.1 23S rRNA pseudouridine(2604) synthase RluF -
ECLTO80_RS01460 300125..300397 - 273 WP_017382612.1 DUF3811 domain-containing protein -
ECLTO80_RS01465 300448..301392 - 945 WP_015570166.1 ketopantoate/pantoate/pantothenate transporter PanS -
ECLTO80_RS01470 301486..302835 - 1350 WP_006810501.1 lysine-sensitive aspartokinase 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11427.21 Da        Isoelectric Point: 10.1042

>T293042 WP_023315213.1 NZ_LS999206:c299054-298752 [Enterobacter hormaechei]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDIRPVGEGISELRIHFGPGYRVYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10088.51 Da        Isoelectric Point: 4.7045

>AT293042 WP_032672198.1 NZ_LS999206:c298745-298458 [Enterobacter hormaechei]
MHKLTPYDPANALVDDEEIAVFMADALETGDSAYIAEALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPSGD

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837F9W8

Antitoxin

Source ID Structure

References