Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4351152..4352196 Replicon chromosome
Accession NZ_LS998785
Organism Escherichia coli isolate EC-TO75

Toxin (Protein)


Gene name panT Uniprot ID A0A829CP20
Locus tag ECTO75_RS21285 Protein ID WP_000019186.1
Coordinates 4351152..4351700 (-) Length 183 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A839B6W4
Locus tag ECTO75_RS21290 Protein ID WP_000287252.1
Coordinates 4351723..4352196 (-) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO75_RS21240 4346364..4346915 - 552 WP_000515860.1 hypothetical protein -
ECTO75_RS21245 4346959..4347159 - 201 WP_000649477.1 helix-turn-helix domain-containing protein -
ECTO75_RS21250 4347250..4347924 + 675 WP_000859462.1 LexA family transcriptional repressor -
ECTO75_RS21265 4348591..4348953 + 363 WP_000135682.1 hypothetical protein -
ECTO75_RS21270 4349019..4349843 + 825 WP_001753751.1 DUF2303 family protein -
ECTO75_RS21275 4350060..4350812 + 753 WP_001701368.1 hypothetical protein -
ECTO75_RS21280 4350849..4351118 + 270 WP_001093912.1 pyocin activator PrtN family protein -
ECTO75_RS21285 4351152..4351700 - 549 WP_000019186.1 hypothetical protein Toxin
ECTO75_RS21290 4351723..4352196 - 474 WP_000287252.1 SocA family protein Antitoxin
ECTO75_RS21295 4352483..4352605 - 123 WP_001300034.1 hypothetical protein -
ECTO75_RS21300 4352968..4353984 - 1017 WP_000912595.1 DUF2713 family protein -
ECTO75_RS21310 4354302..4354817 + 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
ECTO75_RS21315 4354859..4355068 - 210 WP_001030593.1 CsbD family protein -
ECTO75_RS21320 4355184..4356509 - 1326 WP_001301116.1 MATE family efflux transporter DinF -
ECTO75_RS21325 4356582..4357190 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4328364..4357190 28826
- inside Prophage - espX5 / espX4 / espX4 4310223..4367521 57298


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-123)


Sequences

Toxin        


Download         Length: 183 a.a.        Molecular weight: 20026.39 Da        Isoelectric Point: 4.4481

>T293024 WP_000019186.1 NZ_LS998785:c4351700-4351152 [Escherichia coli]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQAFESAFEPSNHERDDDSSSENKAILEEEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVVAMFTSFLIAHEGKAPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDSDKEK

Download         Length: 549 bp

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17298.80 Da        Isoelectric Point: 8.4143

>AT293024 WP_000287252.1 NZ_LS998785:c4352196-4351723 [Escherichia coli]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL

Download         Length: 474 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CP20

Antitoxin

Source ID Structure
AlphaFold DB A0A839B6W4

References