Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4241262..4241759 Replicon chromosome
Accession NZ_LS998785
Organism Escherichia coli isolate EC-TO75

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag ECTO75_RS20705 Protein ID WP_001173343.1
Coordinates 4241262..4241435 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID J7RC38
Locus tag ECTO75_RS20710 Protein ID WP_001425728.1
Coordinates 4241463..4241759 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO75_RS20695 4237932..4239389 + 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -
ECTO75_RS20700 4239626..4241143 + 1518 WP_001295074.1 lysine--tRNA ligase -
ECTO75_RS20705 4241262..4241435 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
ECTO75_RS20710 4241463..4241759 - 297 WP_001425728.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
ECTO75_RS20715 4241986..4242258 - 273 WP_000405647.1 N-acetyltransferase -
ECTO75_RS20720 4242270..4242500 - 231 WP_000371700.1 (4Fe-4S)-binding protein -
ECTO75_RS20725 4242681..4244312 + 1632 WP_001216487.1 sensor histidine kinase -
ECTO75_RS20730 4244309..4245028 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T293023 WP_001173343.1 NZ_LS998785:c4241435-4241262 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11466.99 Da        Isoelectric Point: 4.2544

>AT293023 WP_001425728.1 NZ_LS998785:c4241759-4241463 [Escherichia coli]
MEGKNKFNTYVVSFNYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB J7RC38

References