Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3493627..3494245 Replicon chromosome
Accession NZ_LS998785
Organism Escherichia coli isolate EC-TO75

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag ECTO75_RS17085 Protein ID WP_001291435.1
Coordinates 3494027..3494245 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag ECTO75_RS17080 Protein ID WP_000344800.1
Coordinates 3493627..3494001 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO75_RS17070 3488716..3489909 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
ECTO75_RS17075 3489932..3493081 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
ECTO75_RS17080 3493627..3494001 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
ECTO75_RS17085 3494027..3494245 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
ECTO75_RS17090 3494417..3494968 + 552 WP_000102568.1 maltose O-acetyltransferase -
ECTO75_RS17095 3495084..3495554 + 471 WP_000136192.1 YlaC family protein -
ECTO75_RS17100 3495718..3497268 + 1551 WP_001372022.1 cyclic-guanylate-specific phosphodiesterase PdeB -
ECTO75_RS17105 3497310..3497663 - 354 WP_000878140.1 DUF1428 domain-containing protein -
ECTO75_RS17115 3498042..3498353 + 312 WP_000409911.1 MGMT family protein -
ECTO75_RS17120 3498384..3498956 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T293022 WP_001291435.1 NZ_LS998785:3494027-3494245 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT293022 WP_000344800.1 NZ_LS998785:3493627-3494001 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References