Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1351957..1352582 Replicon chromosome
Accession NZ_LS998785
Organism Escherichia coli isolate EC-TO75

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ECTO75_RS06610 Protein ID WP_000911330.1
Coordinates 1352184..1352582 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag ECTO75_RS06605 Protein ID WP_000450524.1
Coordinates 1351957..1352184 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO75_RS06580 1347760..1348230 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
ECTO75_RS06585 1348230..1348802 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
ECTO75_RS06590 1348948..1349826 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
ECTO75_RS06595 1349843..1350877 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
ECTO75_RS06600 1351090..1351803 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
ECTO75_RS06605 1351957..1352184 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
ECTO75_RS06610 1352184..1352582 + 399 WP_000911330.1 tRNA(fMet)-specific endonuclease VapC Toxin
ECTO75_RS06615 1352729..1353592 + 864 WP_001267507.1 neutral zinc metallopeptidase -
ECTO75_RS06620 1353607..1355622 + 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
ECTO75_RS06625 1355696..1356394 + 699 WP_000679823.1 esterase -
ECTO75_RS06630 1356504..1356704 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T293014 WP_000911330.1 NZ_LS998785:1352184-1352582 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT293014 WP_000450524.1 NZ_LS998785:1351957-1352184 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References