Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 911463..912117 Replicon chromosome
Accession NZ_LS998785
Organism Escherichia coli isolate EC-TO75

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag ECTO75_RS04485 Protein ID WP_000244777.1
Coordinates 911710..912117 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag ECTO75_RS04480 Protein ID WP_000354046.1
Coordinates 911463..911729 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO75_RS04455 906751..907494 + 744 Protein_859 SDR family oxidoreductase -
ECTO75_RS04460 907551..908984 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
ECTO75_RS04465 909029..909340 + 312 WP_001679467.1 N(4)-acetylcytidine aminohydrolase -
ECTO75_RS04470 909504..910163 + 660 WP_000250274.1 hemolysin III family protein -
ECTO75_RS04475 910240..911220 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
ECTO75_RS04480 911463..911729 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
ECTO75_RS04485 911710..912117 + 408 WP_000244777.1 toxin CptA Toxin
ECTO75_RS04490 912157..912678 - 522 WP_001055874.1 flavodoxin FldB -
ECTO75_RS04495 912790..913686 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
ECTO75_RS04500 913711..914421 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ECTO75_RS04505 914427..916160 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T293011 WP_000244777.1 NZ_LS998785:911710-912117 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT293011 WP_000354046.1 NZ_LS998785:911463-911729 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References