Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 5018385..5019643 Replicon chromosome
Accession NZ_LS998783
Organism Pseudomonas aeruginosa isolate

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag PA5486_RS24610 Protein ID WP_003086331.1
Coordinates 5018385..5019140 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PA5486_RS24615 Protein ID WP_003086329.1
Coordinates 5019275..5019643 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PA5486_RS24600 5013556..5016099 + 2544 WP_033955245.1 acyl-homoserine-lactone acylase QuiP -
PA5486_RS24605 5016255..5017616 - 1362 WP_003120632.1 DNA recombination protein RmuC -
PA5486_RS24610 5018385..5019140 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
PA5486_RS24615 5019275..5019643 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PA5486_RS24620 5019716..5021002 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
PA5486_RS24625 5021058..5022647 - 1590 WP_023464367.1 aldehyde dehydrogenase family protein -
PA5486_RS24630 5022726..5023202 + 477 WP_004353334.1 elongation factor GreAB -
PA5486_RS35520 5023205..5023480 - 276 WP_023088486.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T293006 WP_003086331.1 NZ_LS998783:c5019140-5018385 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT293006 WP_003086329.1 NZ_LS998783:c5019643-5019275 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References