Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3957980..3959201 Replicon chromosome
Accession NZ_LS998783
Organism Pseudomonas aeruginosa isolate

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag PA5486_RS19150 Protein ID WP_003110488.1
Coordinates 3958623..3959201 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PA5486_RS19145 Protein ID WP_003088112.1
Coordinates 3957980..3958534 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PA5486_RS19120 3953548..3954099 + 552 WP_003450159.1 XRE family transcriptional regulator -
PA5486_RS19125 3954096..3954494 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PA5486_RS19130 3954507..3954830 - 324 WP_015648646.1 multidrug efflux SMR transporter -
PA5486_RS19135 3955161..3955622 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PA5486_RS19140 3955627..3957822 + 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PA5486_RS19145 3957980..3958534 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
PA5486_RS19150 3958623..3959201 + 579 WP_003110488.1 HD domain-containing protein Toxin
PA5486_RS19155 3959310..3960497 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PA5486_RS19160 3960487..3962658 - 2172 WP_025297367.1 type I secretion system permease/ATPase -
PA5486_RS19165 3962648..3963925 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T293005 WP_003110488.1 NZ_LS998783:3958623-3959201 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT293005 WP_003088112.1 NZ_LS998783:3957980-3958534 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References