293004

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 3017384..3018426 Replicon chromosome
Accession NZ_LS998783
Organism Pseudomonas aeruginosa isolate

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag PA5486_RS14905 Protein ID WP_003153636.1
Coordinates 3017851..3018426 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag PA5486_RS14900 Protein ID WP_003050245.1
Coordinates 3017384..3017854 (+) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PA5486_RS14865 3012776..3014194 - 1419 WP_006226029.1 TIGR03752 family integrating conjugative element protein -
PA5486_RS14870 3014184..3015095 - 912 WP_006226028.1 TIGR03749 family integrating conjugative element protein -
PA5486_RS14875 3015092..3015784 - 693 WP_003090182.1 TIGR03746 family integrating conjugative element protein -
PA5486_RS14880 3015781..3016179 - 399 WP_003050133.1 TIGR03750 family conjugal transfer protein -
PA5486_RS14885 3016191..3016550 - 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
PA5486_RS14890 3016567..3016800 - 234 WP_023101201.1 TIGR03758 family integrating conjugative element protein -
PA5486_RS14895 3016797..3017180 - 384 WP_003090167.1 RAQPRD family integrative conjugative element protein -
PA5486_RS14900 3017384..3017854 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
PA5486_RS14905 3017851..3018426 + 576 WP_003153636.1 PIN domain-containing protein Toxin
PA5486_RS14910 3018444..3019358 + 915 WP_016852809.1 AAA family ATPase -
PA5486_RS14915 3019355..3019825 + 471 WP_003090160.1 hypothetical protein -
PA5486_RS14920 3019822..3020322 + 501 WP_003090159.1 hypothetical protein -
PA5486_RS14925 3020322..3021224 + 903 WP_003090158.1 nucleotidyltransferase domain-containing protein -
PA5486_RS14930 3021263..3021988 + 726 WP_003050273.1 CBASS effector endonuclease NucC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T293004 WP_003153636.1 NZ_LS998783:3017851-3018426 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT293004 WP_003050245.1 NZ_LS998783:3017384-3017854 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References