Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2719503..2720019 Replicon chromosome
Accession NZ_LS998783
Organism Pseudomonas aeruginosa isolate

Toxin (Protein)


Gene name relE Uniprot ID A0A3R8UIH5
Locus tag PA5486_RS13545 Protein ID WP_025297453.1
Coordinates 2719738..2720019 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3R8UIM7
Locus tag PA5486_RS13540 Protein ID WP_025297454.1
Coordinates 2719503..2719748 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PA5486_RS13520 2714625..2714954 - 330 WP_031692728.1 hypothetical protein -
PA5486_RS13525 2715302..2715970 + 669 WP_071534660.1 hypothetical protein -
PA5486_RS13530 2715967..2717073 + 1107 WP_025297456.1 XRE family transcriptional regulator -
PA5486_RS13535 2717204..2719345 + 2142 WP_025297455.1 hypothetical protein -
PA5486_RS13540 2719503..2719748 + 246 WP_025297454.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
PA5486_RS13545 2719738..2720019 + 282 WP_025297453.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PA5486_RS13550 2720425..2721006 - 582 WP_033895412.1 plasmid pRiA4b ORF-3 family protein -
PA5486_RS13555 2721020..2721895 - 876 WP_033895413.1 WYL domain-containing protein -
PA5486_RS13560 2722030..2723604 + 1575 WP_025297452.1 DNA recombination protein RmuC -
PA5486_RS13565 2723628..2724276 + 649 Protein_2612 peptidase M15 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2705982..2773750 67768
- inside Genomic island - - 2693900..2774179 80279


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-71)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10824.61 Da        Isoelectric Point: 10.6249

>T293003 WP_025297453.1 NZ_LS998783:2719738-2720019 [Pseudomonas aeruginosa]
MTYELEFLPSALKEWQKLGHTVREQIKKKLRERLDNPKVQADALRDMPGHYKIKLRASGYRLVYRVEDERVVVVVVAVGK
RERGAAYQSAKGR

Download         Length: 282 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8797.21 Da        Isoelectric Point: 4.2550

>AT293003 WP_025297454.1 NZ_LS998783:2719503-2719748 [Pseudomonas aeruginosa]
MQSILADVAVSVSELKKNPSGILAGAGGMPVAVLNHNRVMGYMVPAELYEQMMERLDDLELVEIVKARSGEESVPVRLDD
L

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R8UIH5

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8UIM7

References