293000

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rnlAB/RnlA-RnlB
Location 1173654..1175075 Replicon chromosome
Accession NZ_LS998783
Organism Pseudomonas aeruginosa isolate

Toxin (Protein)


Gene name rnlA Uniprot ID -
Locus tag PA5486_RS05830 Protein ID WP_025297643.1
Coordinates 1174002..1175075 (-) Length 358 a.a.

Antitoxin (Protein)


Gene name rnlB Uniprot ID -
Locus tag PA5486_RS05825 Protein ID WP_158025315.1
Coordinates 1173654..1173947 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PA5486_RS05780 1168757..1168969 + 213 WP_023128602.1 hypothetical protein -
PA5486_RS05785 1169060..1169515 - 456 WP_025297646.1 helix-turn-helix domain-containing protein -
PA5486_RS05790 1169680..1170075 + 396 WP_023128603.1 hypothetical protein -
PA5486_RS05795 1170118..1170588 + 471 WP_023128604.1 hypothetical protein -
PA5486_RS05800 1170591..1170974 + 384 WP_025297645.1 hypothetical protein -
PA5486_RS05805 1171056..1171634 + 579 WP_025297644.1 hypothetical protein -
PA5486_RS05810 1171965..1172329 + 365 Protein_1116 DNA binding protein -
PA5486_RS05815 1172553..1172747 - 195 WP_023128607.1 OprD family outer membrane porin -
PA5486_RS05820 1172746..1173441 + 696 WP_196747054.1 transporter substrate-binding domain-containing protein -
PA5486_RS05825 1173654..1173947 - 294 WP_158025315.1 type II toxin-antitoxin system RnlB family antitoxin Antitoxin
PA5486_RS05830 1174002..1175075 - 1074 WP_025297643.1 type II toxin-antitoxin system RnlA family toxin Toxin
PA5486_RS05835 1175790..1176044 + 255 WP_023128610.1 hypothetical protein -
PA5486_RS05845 1176342..1176638 + 297 WP_023128612.1 hypothetical protein -
PA5486_RS05850 1176691..1178274 - 1584 WP_025297642.1 hypothetical protein -
PA5486_RS05855 1178554..1178982 + 429 WP_025297641.1 S24 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Bacterial toxin, RNase RnlA/LsoA, N-terminal

(6-87)

Antitoxin

Antitoxin RnlB/LsoB

(2-96)


Sequences

Toxin        


Download         Length: 358 a.a.        Molecular weight: 40381.89 Da        Isoelectric Point: 6.1830

>T293000 WP_025297643.1 NZ_LS998783:c1175075-1174002 [Pseudomonas aeruginosa]
VTERDYKNINLKRCIIEETTHCFIRDNGLKLRSYGDKPGSSGLRVVFGKAGIEDATLDIFFTNVGASTLTYKVGKNQALG
QQLADALYETIHPDEFVTMNLGIKGVDLDDAEALIKELTESANADIEVASRTSADRKHIWKLKSKKNLDELTVTQHENTH
KLQIQGRPLSCYQQLSYLLTELLEINALECILFKKEENRSEFVCAEVAESVLKERFGDCYANLPQTSRRLLLASLCVRLA
SPALPDYCMLVYPELRTLEGAIKQKLAEKNLSNQEESFGGFFTKTNGQFYLKQQYHADVGDAKLQGHLDNAYTFFNKQRH
GLFHMEEMPSVSRMISNITQAVSLCDEAYDHIKNLYS

Download         Length: 1074 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11039.38 Da        Isoelectric Point: 4.5163

>AT293000 WP_158025315.1 NZ_LS998783:c1173947-1173654 [Pseudomonas aeruginosa]
MTVVTATSYENPLSRLSIIASEMRNTSHSSKEIVLFDLLCSNGEEWNRFVSINYNGTDFEKSTCSIVSKSDIPTDLLETQ
TRFFQIHPQYLLDSVLN

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References