Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 692046..692660 Replicon chromosome
Accession NZ_LS998783
Organism Pseudomonas aeruginosa isolate

Toxin (Protein)


Gene name hicA Uniprot ID A6VBH9
Locus tag PA5486_RS03445 Protein ID WP_071534354.1
Coordinates 692046..692228 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A140SDX7
Locus tag PA5486_RS03450 Protein ID WP_012077229.1
Coordinates 692256..692660 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PA5486_RS35270 689017..689160 + 144 WP_153274318.1 hypothetical protein -
PA5486_RS03430 689487..689822 - 336 Protein_656 NERD domain-containing protein -
PA5486_RS03435 689915..691036 - 1122 WP_015649718.1 Fic family protein -
PA5486_RS03440 691295..691431 - 137 Protein_658 integrase -
PA5486_RS03445 692046..692228 + 183 WP_071534354.1 type II toxin-antitoxin system HicA family toxin Toxin
PA5486_RS03450 692256..692660 + 405 WP_012077229.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PA5486_RS03455 692703..693674 - 972 WP_012077228.1 hypothetical protein -
PA5486_RS03460 693659..694357 - 699 WP_033896049.1 hypothetical protein -
PA5486_RS03465 694357..694896 - 540 WP_012074127.1 hypothetical protein -
PA5486_RS03470 694893..695813 - 921 WP_012074128.1 hypothetical protein -
PA5486_RS03475 695810..696520 - 711 WP_012074129.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 689915..745130 55215
- inside Prophage - - 689915..744287 54372


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6702.74 Da        Isoelectric Point: 10.4826

>T292999 WP_071534354.1 NZ_LS998783:692046-692228 [Pseudomonas aeruginosa]
MRSREVIDLLLEDGWYEVAVKGSHHQFKHPSKPGKVTVQHPSSTIPKGTLNNILKQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14670.54 Da        Isoelectric Point: 4.4315

>AT292999 WP_012077229.1 NZ_LS998783:692256-692660 [Pseudomonas aeruginosa]
MKFPVVLHKDPDSDYGVTVPDVPGCFSAGATVSEALANVEEALALHFEGLVTDGEELPQPQDVDAHMKNPDFEGGVWAVV
DFDVTPYLGKAVRFNATLPEHLLQRIDERVKVDKRYQSRSGFLATAAMRELSVA

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6VBH9

Antitoxin

Source ID Structure
AlphaFold DB A0A140SDX7

References