Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 604315..604855 Replicon chromosome
Accession NZ_LS997868
Organism Vibrio cholerae strain NCTC 30

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag D5R51_RS17005 Protein ID WP_000277238.1
Coordinates 604315..604584 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag D5R51_RS17010 Protein ID WP_001258569.1
Coordinates 604577..604855 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D5R51_RS16940 599541..599930 + 390 WP_162892123.1 VOC family protein -
D5R51_RS16945 600126..600449 + 324 WP_114780077.1 DUF3709 domain-containing protein -
D5R51_RS16950 600774..601052 + 279 Protein_598 flavodoxin family protein -
D5R51_RS16955 601109..601204 + 96 WP_119091959.1 acetyltransferase -
D5R51_RS16960 601236..601649 + 414 WP_002029857.1 VOC family protein -
D5R51_RS16970 601854..602567 + 714 WP_185835382.1 Fic family protein -
D5R51_RS16980 602837..603073 + 237 WP_162810550.1 DUF3709 domain-containing protein -
D5R51_RS16990 603407..603631 + 225 Protein_603 VOC family protein -
D5R51_RS16995 603948..604118 + 171 Protein_604 DUF645 family protein -
D5R51_RS17005 604315..604584 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
D5R51_RS17010 604577..604855 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
D5R51_RS17020 605209..605391 + 183 WP_072668508.1 DUF645 family protein -
D5R51_RS17025 605723..605893 + 171 WP_113600562.1 DUF3709 domain-containing protein -
D5R51_RS17030 606226..606642 + 417 WP_119091961.1 DUF1311 domain-containing protein -
D5R51_RS17040 606809..607111 + 303 Protein_610 isochorismatase family protein -
D5R51_RS17045 607167..608208 - 1042 Protein_611 IS481 family transposase -
D5R51_RS17050 608317..608562 + 246 Protein_612 isochorismatase family protein -
D5R51_RS17055 608736..609149 + 414 WP_119091962.1 GNAT family N-acetyltransferase -
D5R51_RS17060 609260..609444 + 185 Protein_614 DUF3709 domain-containing protein -
D5R51_RS17065 609441..609674 + 234 WP_033930090.1 DUF3709 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron blaCARB-7 - 497585..615862 118277
- inside Prophage - - 577112..635317 58205
- inside IScluster/Tn - - 607167..616981 9814


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T292995 WP_000277238.1 NZ_LS997868:c604584-604315 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT292995 WP_001258569.1 NZ_LS997868:c604855-604577 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References