Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 580456..580994 Replicon chromosome
Accession NZ_LS997868
Organism Vibrio cholerae strain NCTC 30

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag D5R51_RS16715 Protein ID WP_000802136.1
Coordinates 580456..580755 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A271VK51
Locus tag D5R51_RS16720 Protein ID WP_001107720.1
Coordinates 580752..580994 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D5R51_RS16675 575511..575729 + 219 WP_162892121.1 DUF3709 domain-containing protein -
D5R51_RS16680 576012..576395 + 384 WP_001081300.1 hypothetical protein -
D5R51_RS16685 576539..577036 + 498 WP_000259904.1 GNAT family N-acetyltransferase -
D5R51_RS16690 577112..578292 + 1181 WP_119091239.1 IS3 family transposase -
D5R51_RS16705 579879..580331 + 453 WP_119091943.1 hypothetical protein -
D5R51_RS16715 580456..580755 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D5R51_RS16720 580752..580994 - 243 WP_001107720.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
D5R51_RS16730 581364..581684 + 321 WP_119091944.1 DUF645 family protein -
D5R51_RS16745 582101..582766 + 666 WP_119091946.1 site-specific DNA-methyltransferase -
D5R51_RS16750 582925..583506 + 582 WP_114813644.1 hypothetical protein -
D5R51_RS16755 583503..583613 + 111 WP_119092152.1 DUF3265 domain-containing protein -
D5R51_RS16760 583799..583981 + 183 WP_000923340.1 DUF645 family protein -
D5R51_RS16765 584241..585137 + 897 WP_097353652.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron blaCARB-7 - 497585..615862 118277
- inside Prophage - - 577112..635317 58205
- flank IS/Tn - - 585263..586303 1040


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T292991 WP_000802136.1 NZ_LS997868:c580755-580456 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8950.82 Da        Isoelectric Point: 4.1677

>AT292991 WP_001107720.1 NZ_LS997868:c580994-580752 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLVEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A271VK51

References