Detailed information of TA system TA029299

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 4107898..4108423
• Replicon: chromosome
• Accession: NC_020908
• Organism: Octadecabacter arcticus 238

Toxin (Protein)

• Gene name: relE
• Uniprot ID: M9RMG5
• Locus tag: OA238_RS21250
• Protein ID: WP_015496801.1
• Coordinates: 4107898..4108188 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M9RVE3
• Locus tag: OA238_RS21255
• Protein ID: WP_015496802.1
• Coordinates: 4108178..4108423 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OA238_RS21225	4103178..4103777	+	600	WP_015496796.1	hypothetical protein	-
OA238_RS21230	4103774..4104334	+	561	WP_015496797.1	hypothetical protein	-
OA238_RS21235	4104669..4105076	+	408	WP_015496798.1	hypothetical protein	-
OA238_RS21240	4105080..4107671	+	2592	WP_015496799.1	prophage-associated protein	-
OA238_RS21245	4107671..4107901	+	231	WP_015496800.1	hypothetical protein	-
OA238_RS21250	4107898..4108188	-	291	WP_015496801.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OA238_RS21255	4108178..4108423	-	246	WP_015496802.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
OA238_RS21260	4108525..4108836	+	312	WP_015496803.1	phage holin family protein	-
OA238_RS21265	4108925..4109152	+	228	WP_044037311.1	hypothetical protein	-
OA238_RS21270	4109259..4110191	+	933	WP_015496804.1	TIGR02594 family protein	-
OA238_RS33050	4110188..4110445	+	258	WP_015496805.1	hypothetical protein	-
OA238_RS21280	4110578..4110931	+	354	WP_015496806.1	hypothetical protein	-
OA238_RS21285	4110928..4111134	+	207	WP_044037313.1	hypothetical protein	-
OA238_RS21290	4111134..4112249	+	1116	WP_044037315.1	head decoration protein	-
OA238_RS21295	4112328..4112618	+	291	WP_015496808.1	hypothetical protein	-
OA238_RS33055	4112621..4113403	+	783	WP_015496809.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4083733..4133021	49288

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-69)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10918.77 Da
• Isoelectric Point: 10.5034

>T29299 WP_015496801.1 NC_020908:c4108188-4107898 [Octadecabacter arcticus 238]
MRYELQFLPSALKEWQKLGSTLQAQFKKKLIACLAQPQVPADALHGMQDHYKIKLRSAGYRLVYRVEETSITVTVVAVGK
RERSAVYKAAQKRADP

Nucleotide

• Length: 291 bp

>T29299 NC_020908:c4108188-4107898 [Octadecabacter arcticus 238]
ATGCGCTATGAGCTGCAGTTTTTGCCATCCGCACTCAAGGAATGGCAAAAACTTGGATCCACGCTTCAGGCACAGTTCAA
AAAGAAGTTGATCGCGTGCCTCGCCCAGCCTCAGGTGCCTGCTGACGCGCTGCATGGCATGCAAGACCACTATAAGATCA
AGCTGCGCAGTGCCGGCTACCGATTGGTCTACCGCGTGGAAGAGACTTCCATCACAGTCACGGTCGTGGCAGTTGGTAAA
CGCGAGCGCAGCGCAGTCTATAAAGCGGCGCAAAAACGCGCAGATCCTTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8993.40 Da
• Isoelectric Point: 5.0495

>AT29299 WP_015496802.1 NC_020908:c4108423-4108178 [Octadecabacter arcticus 238]
MQRVEANIAVSVSDLKKNPSQVMAQADGEPVAVLNHNRVMAYMVPAARYEAMMEHLDDLELAEMIKRRAGETPVRVSLDA
L

Nucleotide

• Length: 246 bp

>AT29299 NC_020908:c4108423-4108178 [Octadecabacter arcticus 238]
ATGCAGCGTGTCGAAGCCAATATCGCCGTCAGCGTCTCTGATCTCAAAAAAAACCCATCGCAGGTCATGGCACAGGCGGA
CGGTGAGCCCGTTGCTGTGCTCAACCACAACCGTGTCATGGCCTACATGGTGCCCGCCGCGCGCTATGAGGCCATGATGG
AACATCTAGACGATTTGGAACTCGCCGAGATGATCAAGCGGCGCGCGGGTGAGACACCGGTTCGGGTCAGCCTGGATGCG
CTATGA

Structures

Toxin

• AlphaFold DB: M9RMG5

Antitoxin

• AlphaFold DB: M9RVE3