Detailed information of TA system TA292984

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2078113..2079581
• Replicon: chromosome
• Accession: NZ_LS997867
• Organism: Vibrio cholerae strain NCTC 30

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: D5R51_RS09595
• Protein ID: WP_162891998.1
• Coordinates: 2078113..2079117 (+)
• Length: 335 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: D5R51_RS09600
• Protein ID: WP_033837946.1
• Coordinates: 2079114..2079581 (+)
• Length: 156 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D5R51_RS09560	2073638..2075302	+	1665	WP_000879550.1	DNA repair protein RecN	-
D5R51_RS09565	2075461..2075820	+	360	WP_162891997.1	outer membrane protein assembly factor BamE	-
D5R51_RS09570	2075905..2076210	-	306	WP_002020668.1	RnfH family protein	-
D5R51_RS09575	2076213..2076647	-	435	WP_000815880.1	type II toxin-antitoxin system RatA family toxin	-
D5R51_RS09580	2076831..2077316	+	486	WP_000162689.1	SsrA-binding protein SmpB	-
D5R51_RS09595	2078113..2079117	+	1005	WP_162891998.1	type II toxin-antitoxin system HipA family toxin	Toxin
D5R51_RS09600	2079114..2079581	+	468	WP_033837946.1	helix-turn-helix domain-containing protein	Antitoxin
D5R51_RS09605	2080020..2080598	+	579	WP_000109982.1	class I SAM-dependent methyltransferase	-
D5R51_RS09610	2080602..2083550	+	2949	WP_119091406.1	DEAD/DEAH box helicase family protein	-
D5R51_RS09615	2083621..2084571	+	951	WP_119091407.1	NERD domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (199-266)

Antitoxin

• Cro/C1-type helix-turn-helix domain (80-138)

Sequences

Toxin

Protein

• Length: 335 a.a.
• Molecular weight: 37642.90 Da
• Isoelectric Point: 5.0166

>T292984 WP_162891998.1 NZ_LS997867:2078113-2079117 [Vibrio cholerae]
MEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHYDKDDFHAVSLNHPVSFIFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSIDDVKNRAGDFLDYAQQRGAAA
GGATGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAFVIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIY
DFAPMKADPEGIPRTTKWKAPLEVGGTYDFVGIADTLSDLVPKEMLLKELAITASKCVGLKQRLALRGVPEQILEMPAVG
LNYLSEKLTKWGLL

Nucleotide

• Length: 1005 bp

Antitoxin

Protein

• Length: 156 a.a.
• Molecular weight: 17101.65 Da
• Isoelectric Point: 10.7084

>AT292984 WP_033837946.1 NZ_LS997867:2079114-2079581 [Vibrio cholerae]
MKPSNKESVQDTVARLRANRNQQQPKVGKNATHSIKEQTPLDTPTRSKASKNVKAVSAAERKTEANKIIKHLLLGELTQG
QALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFSLKIGLLPSSPDALKSLLMDGEDG

Nucleotide

• Length: 468 bp