Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 98370..98895 Replicon plasmid 2
Accession NZ_LS992193
Organism Escherichia coli isolate Escherichia coli str. TO217

Toxin (Protein)


Gene name ccdB Uniprot ID S1PFV8
Locus tag ECTO217_RS27435 Protein ID WP_001159871.1
Coordinates 98370..98675 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID H9TJP1
Locus tag ECTO217_RS27440 Protein ID WP_000813630.1
Coordinates 98677..98895 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO217_RS27420 94332..95498 - 1167 WP_000772446.1 plasmid-partitioning protein SopA -
ECTO217_RS27425 96086..96841 - 756 WP_000852146.1 replication initiation protein RepE -
ECTO217_RS27430 97563..98369 - 807 WP_000016970.1 site-specific integrase -
ECTO217_RS27435 98370..98675 - 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB Toxin
ECTO217_RS27440 98677..98895 - 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
ECTO217_RS27450 99455..99685 + 231 WP_001261286.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
ECTO217_RS27455 99682..100098 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin -
ECTO217_RS27460 100173..101738 + 1566 WP_001128474.1 AAA family ATPase -
ECTO217_RS27465 101723..102745 + 1023 WP_000361402.1 helicase UvrD -
ECTO217_RS27470 102999..103685 - 687 Protein_128 IS1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - iutA / iucD 1..128948 128948


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11692.49 Da        Isoelectric Point: 6.4674

>T292969 WP_001159871.1 NZ_LS992193:c98675-98370 [Escherichia coli]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8354.27 Da        Isoelectric Point: 4.5203

>AT292969 WP_000813630.1 NZ_LS992193:c98895-98677 [Escherichia coli]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTLQNEARRLRAERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CCE8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CEF5

References