292955

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4422357..4423177 Replicon chromosome
Accession NZ_LS992192
Organism Escherichia coli isolate Escherichia coli str. TO217

Toxin (Protein)


Gene name yjhX Uniprot ID B6I030
Locus tag ECTO217_RS22390 Protein ID WP_001054379.1
Coordinates 4422357..4422614 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag ECTO217_RS22395 Protein ID WP_000123957.1
Coordinates 4422626..4423177 (+) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO217_RS22370 4417904..4418884 + 981 WP_000991462.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
ECTO217_RS22375 4419467..4420573 - 1107 Protein_4301 helicase YjhR -
ECTO217_RS22380 4420636..4421783 + 1148 WP_085949154.1 IS3-like element ISEc52 family transposase -
ECTO217_RS22385 4421816..4421980 + 165 Protein_4303 GNAT family N-acetyltransferase -
ECTO217_RS22390 4422357..4422614 + 258 WP_001054379.1 YjhX family toxin Toxin
ECTO217_RS22395 4422626..4423177 + 552 WP_000123957.1 N-acetyltransferase Antitoxin
ECTO217_RS22400 4423229..4423975 + 747 WP_000354249.1 class I SAM-dependent methyltransferase -
ECTO217_RS22405 4424103..4424363 + 261 WP_000077645.1 hypothetical protein -
ECTO217_RS28520 4424401..4424517 + 117 Protein_4308 VOC family protein -
ECTO217_RS22410 4424762..4425883 + 1122 WP_000010833.1 M42 family metallopeptidase -
ECTO217_RS22415 4425880..4426158 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
ECTO217_RS22420 4426170..4427483 + 1314 WP_000460845.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimE 4410978..4431398 20420


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(19-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9568.07 Da        Isoelectric Point: 11.1381

>T292955 WP_001054379.1 NZ_LS992192:4422357-4422614 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 20358.34 Da        Isoelectric Point: 6.4182

>AT292955 WP_000123957.1 NZ_LS992192:4422626-4423177 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Download         Length: 552 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B6I030

Antitoxin

Source ID Structure

References