292953

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4262934..4263454 Replicon chromosome
Accession NZ_LS992192
Organism Escherichia coli isolate Escherichia coli str. TO217

Toxin (Protein)


Gene name ccdB Uniprot ID A0A061KX66
Locus tag ECTO217_RS21620 Protein ID WP_001160964.1
Coordinates 4262934..4263218 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag ECTO217_RS21625 Protein ID WP_000125566.1
Coordinates 4263221..4263454 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO217_RS21595 4258579..4259865 + 1287 WP_000800457.1 peptidylprolyl isomerase SurA -
ECTO217_RS21600 4259865..4260854 + 990 WP_000241227.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
ECTO217_RS21605 4260851..4261672 + 822 WP_001065365.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
ECTO217_RS21610 4261675..4262052 + 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
ECTO217_RS21615 4262059..4262907 + 849 WP_000257181.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
ECTO217_RS21620 4262934..4263218 - 285 WP_001160964.1 CcdB family protein Toxin
ECTO217_RS21625 4263221..4263454 - 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
ECTO217_RS21630 4263540..4264019 - 480 WP_000624375.1 type 3 dihydrofolate reductase -
ECTO217_RS21635 4264211..4266073 - 1863 WP_000377106.1 glutathione-regulated potassium-efflux system protein KefC -
ECTO217_RS21640 4266066..4266596 - 531 WP_000600725.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
ECTO217_RS21645 4266704..4268035 - 1332 WP_001183209.1 MFS transporter -
ECTO217_RS21650 4268094..4268381 - 288 WP_000203744.1 ferredoxin-like protein FixX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-93)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10692.54 Da        Isoelectric Point: 10.3030

>T292953 WP_001160964.1 NZ_LS992192:c4263218-4262934 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLIDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIK

Download         Length: 285 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT292953 WP_000125566.1 NZ_LS992192:c4263454-4263221 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061KX66

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References