Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 952272..952926 Replicon chromosome
Accession NZ_LS992192
Organism Escherichia coli isolate Escherichia coli str. TO217

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag ECTO217_RS04765 Protein ID WP_000244765.1
Coordinates 952519..952926 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag ECTO217_RS04760 Protein ID WP_000354050.1
Coordinates 952272..952538 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO217_RS04740 948360..949793 - 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -
ECTO217_RS04745 949838..950149 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
ECTO217_RS04750 950313..950972 + 660 WP_000250275.1 hemolysin III family protein -
ECTO217_RS04755 951049..952029 - 981 WP_000886084.1 tRNA-modifying protein YgfZ -
ECTO217_RS04760 952272..952538 + 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
ECTO217_RS04765 952519..952926 + 408 WP_000244765.1 protein YgfX Toxin
ECTO217_RS04770 952966..953487 - 522 WP_001055874.1 flavodoxin FldB -
ECTO217_RS04775 953599..954495 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
ECTO217_RS04780 954520..955230 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ECTO217_RS04785 955236..956969 + 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T292942 WP_000244765.1 NZ_LS992192:952519-952926 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT292942 WP_000354050.1 NZ_LS992192:952272-952538 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References