292938

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 288920..289720 Replicon chromosome
Accession NZ_LS992192
Organism Escherichia coli isolate Escherichia coli str. TO217

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag ECTO217_RS01350 Protein ID WP_000342452.1
Coordinates 289193..289720 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag ECTO217_RS01345 Protein ID WP_001277107.1
Coordinates 288920..289186 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO217_RS01325 284579..285247 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
ECTO217_RS01330 285240..286298 + 1059 WP_001042013.1 permease-like cell division protein FtsX -
ECTO217_RS01335 286543..287397 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
ECTO217_RS01340 287668..288771 + 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
ECTO217_RS01345 288920..289186 + 267 WP_001277107.1 DUF1778 domain-containing protein Antitoxin
ECTO217_RS01350 289193..289720 + 528 WP_000342452.1 GNAT family N-acetyltransferase Toxin
ECTO217_RS01355 289717..290100 - 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
ECTO217_RS01360 290523..291632 + 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
ECTO217_RS01365 291680..292606 + 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
ECTO217_RS01370 292603..293880 + 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
ECTO217_RS01375 293877..294644 + 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T292938 WP_000342452.1 NZ_LS992192:289193-289720 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT292938 WP_001277107.1 NZ_LS992192:288920-289186 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References