Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 423922..424749 Replicon
Accession NC_020887
Organism Clostridium stercorarium subsp. stercorarium DSM 8532

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag CLST_RS01810 Protein ID WP_015484857.1
Coordinates 423922..424386 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID L7VL72
Locus tag CLST_RS01815 Protein ID WP_015358106.1
Coordinates 424408..424749 (-) Length 114 a.a.

Genomic Context

CLST_RS01785CLST_RS13145CLST_RS13275CLST_RS01820CLST_RS01825CLST_RS01830CLST_RS01835CLST_RS01840CLST_RS01845CLST_RS01850CLST_RS01790CLST_RS01795CLST_RS01805CLST_RS01810CLST_RS01815
Location: 419011..419442 (432 bp)
Type: Others
Protein ID: WP_015358101.1
Location: 420665..420883 (219 bp)
Type: Others
Protein ID: Protein_340
Location: 422179..422331 (153 bp)
Type: Others
Protein ID: Protein_342
Location: 424896..425096 (201 bp)
Type: Others
Protein ID: WP_015358107.1
Location: 425136..425330 (195 bp)
Type: Others
Protein ID: WP_015484858.1
Location: 425352..425549 (198 bp)
Type: Others
Protein ID: WP_015358108.1
Location: 425705..425884 (180 bp)
Type: Others
Protein ID: WP_015358109.1
Location: 425943..426872 (930 bp)
Type: Others
Protein ID: WP_015358110.1
Location: 426887..427702 (816 bp)
Type: Others
Protein ID: WP_015358111.1
Location: 428133..429011 (879 bp)
Type: Others
Protein ID: WP_015358113.1
Location: 420326..420457 (132 bp)
Type: Others
Protein ID: Protein_339
Location: 420892..422118 (1227 bp)
Type: Others
Protein ID: WP_015358103.1
Location: 422700..423917 (1218 bp)
Type: Others
Protein ID: WP_015358104.1
Location: 423922..424386 (465 bp)
Type: Toxin
Protein ID: WP_015484857.1
Location: 424408..424749 (342 bp)
Type: Antitoxin
Protein ID: WP_015358106.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CLST_RS01785419011..419442+432WP_015358101.1hypothetical protein-
CLST_RS01790420326..420457-132Protein_339helix-turn-helix domain-containing protein-
CLST_RS13145420665..420883+219Protein_340helix-turn-helix domain-containing protein-
CLST_RS01795420892..422118-1227WP_015358103.1IS256 family transposase-
CLST_RS13275422179..422331+153Protein_342IS30 family transposase-
CLST_RS01805422700..423917-1218WP_015358104.1site-specific integrase-
CLST_RS01810423922..424386-465WP_015484857.1ImmA/IrrE family metallo-endopeptidaseToxin
CLST_RS01815424408..424749-342WP_015358106.1helix-turn-helix domain-containing proteinAntitoxin
CLST_RS01820424896..425096+201WP_015358107.1transcriptional regulator-
CLST_RS01825425136..425330+195WP_015484858.1helix-turn-helix domain-containing protein-
CLST_RS01830425352..425549+198WP_015358108.1hypothetical protein-
CLST_RS01835425705..425884+180WP_015358109.1hypothetical protein-
CLST_RS01840425943..426872+930WP_015358110.1YqaJ viral recombinase family protein-
CLST_RS01845426887..427702+816WP_015358111.1recombination protein RecT-
CLST_RS01850428133..429011+879WP_015358113.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--420734..46063839904


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(14-120)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17967.60 Da        Isoelectric Point: 6.9505

>T29293 WP_015484857.1 NC_020887:c424386-423922 [Thermoclostridium stercorarium subsp. stercorarium DSM 8532]
MLYEFLLIKADNEGINVYEKEIGKLKGLYFDGNIIINSSIETNSEKACILAEELGHHYTTHGNILNQCKVENRKQERRAR
AWAYERLVSLNSLIEASKHCIRNRFELAEFLGVSERFIDEAIQYYKEKYGICHKVGDYIVYFEPLGVLKKVQKE

Download         Length: 465 bp

>T29293 NC_020887:c424386-423922 [Thermoclostridium stercorarium subsp. stercorarium DSM 8532]
TTGCTTTATGAATTTCTTCTCATCAAGGCCGACAACGAAGGTATAAATGTATATGAAAAGGAAATCGGGAAATTAAAAGG
ATTATACTTTGACGGAAATATAATAATTAATTCTTCAATCGAAACAAATTCTGAAAAAGCCTGTATTTTAGCCGAAGAAT
TGGGACATCATTATACGACCCATGGAAATATATTGAACCAATGTAAAGTAGAAAACAGAAAACAGGAACGTCGGGCCCGC
GCTTGGGCATACGAACGACTGGTAAGTTTGAATAGCCTGATAGAGGCATCTAAACATTGTATCAGAAATAGATTTGAGTT
AGCTGAATTTTTGGGTGTATCCGAACGTTTTATTGATGAGGCAATTCAATATTACAAAGAAAAGTATGGTATTTGCCACA
AAGTTGGAGATTACATAGTTTATTTTGAACCTTTAGGAGTTCTAAAAAAAGTACAAAAGGAGTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12856.79 Da        Isoelectric Point: 8.3707

>AT29293 WP_015358106.1 NC_020887:c424749-424408 [Thermoclostridium stercorarium subsp. stercorarium DSM 8532]
MAIGDRIKKLRIEKGMTQEELAKYIDSTKQTIYKYENNIVTNIPSDKIEKIAEALGTTPSYLMGWNDTASKNNVKKPITV
AAHIPDGVELTEEDIKQINDFIQFIISKKKDQK

Download         Length: 342 bp

>AT29293 NC_020887:c424749-424408 [Thermoclostridium stercorarium subsp. stercorarium DSM 8532]
TTGGCTATTGGTGATAGAATAAAAAAACTCAGAATAGAAAAAGGCATGACACAGGAAGAATTGGCCAAATATATTGATTC
CACCAAACAAACAATTTACAAATATGAAAATAACATTGTGACTAATATTCCCTCTGATAAGATTGAAAAAATTGCAGAGG
CATTAGGAACGACACCTTCTTATTTAATGGGCTGGAACGATACAGCTTCCAAAAATAATGTTAAAAAGCCCATCACTGTT
GCCGCACATATTCCTGATGGCGTTGAACTTACTGAGGAAGATATAAAACAAATCAATGACTTCATACAGTTCATTATTTC
AAAAAAGAAGGATCAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBL7VL72

References