Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4364352..4365172 Replicon chromosome
Accession NZ_LS992190
Organism Escherichia coli isolate Escherichia coli str. TO148

Toxin (Protein)


Gene name yjhX Uniprot ID B6I030
Locus tag ECTO148_RS21845 Protein ID WP_001054379.1
Coordinates 4364352..4364609 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag ECTO148_RS21850 Protein ID WP_000123957.1
Coordinates 4364621..4365172 (+) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO148_RS21825 4359899..4360879 + 981 WP_000991462.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
ECTO148_RS21830 4361462..4362568 - 1107 Protein_4181 helicase YjhR -
ECTO148_RS21835 4362631..4363778 + 1148 WP_085949154.1 IS3-like element ISEc52 family transposase -
ECTO148_RS21840 4363811..4363975 + 165 Protein_4183 GNAT family N-acetyltransferase -
ECTO148_RS21845 4364352..4364609 + 258 WP_001054379.1 YjhX family toxin Toxin
ECTO148_RS21850 4364621..4365172 + 552 WP_000123957.1 N-acetyltransferase Antitoxin
ECTO148_RS21855 4365224..4365970 + 747 WP_000354249.1 class I SAM-dependent methyltransferase -
ECTO148_RS21860 4366098..4366358 + 261 WP_000077645.1 hypothetical protein -
ECTO148_RS26655 4366396..4366512 + 117 Protein_4188 VOC family protein -
ECTO148_RS21865 4366757..4367878 + 1122 WP_000010833.1 M42 family metallopeptidase -
ECTO148_RS21870 4367875..4368153 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
ECTO148_RS21875 4368165..4369478 + 1314 WP_000460845.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimE 4352973..4373393 20420


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(19-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9568.07 Da        Isoelectric Point: 11.1381

>T292929 WP_001054379.1 NZ_LS992190:4364352-4364609 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 20358.34 Da        Isoelectric Point: 6.4182

>AT292929 WP_000123957.1 NZ_LS992190:4364621-4365172 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Download         Length: 552 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B6I030

Antitoxin

Source ID Structure

References