Detailed information of TA system TA292926

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3937324..3939013
• Replicon: chromosome
• Accession: NZ_LS992190
• Organism: Escherichia coli isolate Escherichia coli str. TO148

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: ECTO148_RS19790
• Protein ID: WP_000365807.1
• Coordinates: 3937324..3938244 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: ECTO148_RS19795
• Protein ID: WP_001295795.1
• Coordinates: 3938231..3939013 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECTO148_RS19750	3932797..3933507	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
ECTO148_RS19755	3933814..3934143	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
ECTO148_RS19760	3934155..3934318	-	164	Protein_3779	tail fiber assembly protein	-
ECTO148_RS19765	3934392..3935006	-	615	WP_001019923.1	YagU family protein	-
ECTO148_RS19770	3935221..3935406	-	186	WP_000146240.1	hypothetical protein	-
ECTO148_RS26565	3935455..3935613	+	159	Protein_3782	integrase	-
ECTO148_RS19780	3935840..3936175	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
ECTO148_RS19785	3936383..3937159	+	777	WP_000171155.1	site-specific integrase	-
ECTO148_RS19790	3937324..3938244	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
ECTO148_RS19795	3938231..3939013	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
ECTO148_RS19800	3939297..3942395	+	3099	WP_000673070.1	type I restriction endonuclease subunit R	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3897108..3946076	48968

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T292926 WP_000365807.1 NZ_LS992190:c3938244-3937324 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT292926 WP_001295795.1 NZ_LS992190:c3939013-3938231 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0