29292

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 2002544..2003194 Replicon chromosome
Accession NC_020834
Organism Mannheimia haemolytica USDA-ARS-USMARC-185

Toxin (Protein)


Gene name vapC Uniprot ID A0A547EDJ6
Locus tag D648_RS09965 Protein ID WP_006249411.1
Coordinates 2002544..2002933 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A547EDM1
Locus tag D648_RS09970 Protein ID WP_006249412.1
Coordinates 2002934..2003194 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D648_RS09920 1998023..1998832 - 810 WP_006250123.1 metal ABC transporter permease -
D648_RS09925 1998825..1999685 - 861 WP_006250124.1 metal ABC transporter permease -
D648_RS09930 1999759..2000544 - 786 WP_006251768.1 hypothetical protein -
D648_RS09960 2001286..2002524 - 1239 WP_006253630.1 peptidase T -
D648_RS09965 2002544..2002933 - 390 WP_006249411.1 type II toxin-antitoxin system VapC family toxin Toxin
D648_RS09970 2002934..2003194 - 261 WP_006249412.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
D648_RS09975 2003310..2003522 - 213 WP_006251765.1 BrnA antitoxin family protein -
D648_RS09980 2003523..2003810 - 288 WP_006251764.1 BrnT family toxin -
D648_RS09985 2003973..2007506 - 3534 WP_006253629.1 transcription-repair coupling factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14633.91 Da        Isoelectric Point: 7.1041

>T29292 WP_006249411.1 NC_020834:c2002933-2002544 [Mannheimia haemolytica USDA-ARS-USMARC-185]
MYMLDTNTVSYFFRGNANVVAKLKSINPERLCISSVTAAELVYGVAKRNNGQLSQFLDYFLSSVKVLDWNYRCAELYGKL
RAEMEKNGKVMGVQDQMIASHALAEECILVSSDQAFKMVPDLKLENWLH

Download         Length: 390 bp

>T29292 NC_020834:c2002933-2002544 [Mannheimia haemolytica USDA-ARS-USMARC-185]
ATGTATATGTTAGATACGAATACTGTAAGCTATTTTTTTCGTGGAAATGCAAATGTGGTGGCGAAATTGAAGTCCATTAA
TCCTGAGAGGCTTTGTATTTCATCTGTAACTGCTGCTGAATTGGTTTATGGTGTGGCGAAAAGAAATAATGGGCAGCTTT
CTCAATTTTTAGATTATTTTTTATCGAGTGTAAAGGTTTTAGATTGGAATTATCGTTGTGCTGAACTTTATGGAAAGTTA
CGGGCAGAGATGGAGAAAAATGGCAAAGTAATGGGCGTGCAGGATCAAATGATTGCTAGTCACGCTCTTGCTGAAGAGTG
TATTTTAGTTTCTAGTGATCAGGCATTTAAAATGGTACCTGATCTGAAATTGGAGAATTGGTTACACTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10245.54 Da        Isoelectric Point: 4.8951

>AT29292 WP_006249412.1 NC_020834:c2003194-2002934 [Mannheimia haemolytica USDA-ARS-USMARC-185]
MEKIARLFRNGRNQAVRLPVEFEFDAEQVYVSKKENGDILLSLRSRNTEHWQRLFELLPAVVCDETFLDTKERNQSFEQR
DPFEVA

Download         Length: 261 bp

>AT29292 NC_020834:c2003194-2002934 [Mannheimia haemolytica USDA-ARS-USMARC-185]
ATGGAAAAAATTGCGAGATTATTCCGTAACGGGCGGAACCAAGCAGTGCGTTTACCGGTTGAATTTGAGTTTGATGCAGA
GCAAGTCTATGTTTCTAAAAAAGAAAATGGCGATATTTTATTATCATTGAGATCGAGAAATACCGAGCATTGGCAACGAT
TGTTTGAGCTATTGCCTGCTGTTGTATGTGATGAAACATTTTTAGATACAAAAGAGAGAAACCAATCCTTTGAGCAACGG
GATCCTTTTGAGGTAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A547EDJ6

Antitoxin

Source ID Structure
AlphaFold DB A0A547EDM1

References