292916

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1037206..1037860 Replicon chromosome
Accession NZ_LS992190
Organism Escherichia coli isolate Escherichia coli str. TO148

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag ECTO148_RS05210 Protein ID WP_000244765.1
Coordinates 1037453..1037860 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag ECTO148_RS05205 Protein ID WP_000354050.1
Coordinates 1037206..1037472 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO148_RS05185 1033294..1034727 - 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -
ECTO148_RS05190 1034772..1035083 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
ECTO148_RS05195 1035247..1035906 + 660 WP_000250275.1 hemolysin III family protein -
ECTO148_RS05200 1035983..1036963 - 981 WP_000886084.1 tRNA-modifying protein YgfZ -
ECTO148_RS05205 1037206..1037472 + 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
ECTO148_RS05210 1037453..1037860 + 408 WP_000244765.1 protein YgfX Toxin
ECTO148_RS05215 1037900..1038421 - 522 WP_001055874.1 flavodoxin FldB -
ECTO148_RS05220 1038533..1039429 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
ECTO148_RS05225 1039454..1040164 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ECTO148_RS05230 1040170..1041903 + 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T292916 WP_000244765.1 NZ_LS992190:1037453-1037860 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT292916 WP_000354050.1 NZ_LS992190:1037206-1037472 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References