292914

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 887711..888992 Replicon chromosome
Accession NZ_LS992190
Organism Escherichia coli isolate Escherichia coli str. TO148

Toxin (Protein)


Gene name sanaT Uniprot ID A0A1X3JHM4
Locus tag ECTO148_RS04330 Protein ID WP_001114681.1
Coordinates 887711..888604 (-) Length 298 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID V0YCI1
Locus tag ECTO148_RS04335 Protein ID WP_000208383.1
Coordinates 888597..888992 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECTO148_RS04310 882861..883844 - 984 WP_001296394.1 KpsF/GutQ family sugar-phosphate isomerase -
ECTO148_RS04315 884470..885225 - 756 Protein_832 IS21-like element ISEc10 family helper ATPase IstB -
ECTO148_RS04320 885222..886721 - 1500 WP_000174401.1 IS21-like element ISEc10 family transposase -
ECTO148_RS04325 887070..887240 - 171 Protein_834 IS110 family transposase -
ECTO148_RS04330 887711..888604 - 894 WP_001114681.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
ECTO148_RS04335 888597..888992 - 396 WP_000208383.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
ECTO148_RS04340 889061..889906 - 846 WP_023281696.1 DUF4942 domain-containing protein -
ECTO148_RS04345 889991..890188 - 198 WP_000839293.1 DUF957 domain-containing protein -
ECTO148_RS04350 890205..890693 - 489 WP_000761699.1 hypothetical protein -
ECTO148_RS04355 890690..891067 - 378 WP_000854689.1 TA system toxin CbtA family protein -
ECTO148_RS04360 891144..891524 - 381 WP_001285598.1 type IV toxin-antitoxin system YeeU family antitoxin -
ECTO148_RS04365 891574..892218 - 645 WP_000094916.1 hypothetical protein -
ECTO148_RS04370 892237..892458 - 222 WP_000692329.1 DUF987 domain-containing protein -
ECTO148_RS04375 892521..892997 - 477 WP_001186726.1 RadC family protein -
ECTO148_RS04380 893013..893498 - 486 WP_000849566.1 antirestriction protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(34-292)

Antitoxin

Protein of unknown function DUF6088

(10-129)


Sequences

Toxin        


Download         Length: 298 a.a.        Molecular weight: 34298.40 Da        Isoelectric Point: 5.9850

>T292914 WP_001114681.1 NZ_LS992190:c888604-887711 [Escherichia coli]
MPELTSLFPDVADALDIESVAIVEKDYFVVDLLRLLKEIKPETHTLVFAGSTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVIHNSDIFSLDNENARITRDEYRYNEISVRYPQTFAQVPCLRPFIKLELMESTLLEHPESR
DIYSLVTELTGKGTPITAFPCATILSTQAEKLISMMRRTAAHLRNPEQQDDEFLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQYPQFCSSPVDELKKGLDALRDYPVHKLRFQRFVNPMVFGNTQIN

Download         Length: 894 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14608.03 Da        Isoelectric Point: 11.3150

>AT292914 WP_000208383.1 NZ_LS992190:c888992-888597 [Escherichia coli]
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNIITGKIMPAAPGGSAAVITE
ALERLNIRYRLAGATECYNKGQSTQIPVSLGIKTPSRFKRVLIVGKSKINA

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3JHM4

Antitoxin

Source ID Structure
AlphaFold DB V0YCI1

References