Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 45960..46795 Replicon chromosome
Accession NZ_LS992190
Organism Escherichia coli isolate Escherichia coli str. TO148

Toxin (Protein)


Gene name yeeV Uniprot ID A0A376WVB1
Locus tag ECTO148_RS00240 Protein ID WP_001094448.1
Coordinates 45960..46337 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3T7EC32
Locus tag ECTO148_RS00245 Protein ID WP_024175935.1
Coordinates 46427..46795 (-) Length 123 a.a.

Genomic Context

ECTO148_RS00210ECTO148_RS00215ECTO148_RS00220ECTO148_RS00225ECTO148_RS00230ECTO148_RS00235ECTO148_RS00240ECTO148_RS00245ECTO148_RS00250ECTO148_RS00255ECTO148_RS00260ECTO148_RS00265ECTO148_RS00270ECTO148_RS00275ECTO148_RS00280
Location: 41328..42146 (819 bp)
Type: Others
Protein ID: WP_000779409.1
Location: 42150..43073 (924 bp)
Type: Others
Protein ID: WP_000535950.1
Location: 43251..43748 (498 bp)
Type: Others
Protein ID: WP_000509815.1
Location: 44341..45186 (846 bp)
Type: Others
Protein ID: WP_000065751.1
Location: 45242..45463 (222 bp)
Type: Others
Protein ID: WP_001296561.1
Location: 45475..45963 (489 bp)
Type: Others
Protein ID: WP_000761714.1
Location: 45960..46337 (378 bp)
Type: Toxin
Protein ID: WP_001094448.1
Location: 46427..46795 (369 bp)
Type: Antitoxin
Protein ID: WP_024175935.1
Location: 46869..47090 (222 bp)
Type: Others
Protein ID: WP_000692346.1
Location: 47159..47368 (210 bp)
Type: Others
Protein ID: Protein_50
Location: 47452..48198 (747 bp)
Type: Others
Protein ID: WP_001016257.1
Location: 48213..49754 (1542 bp)
Type: Others
Protein ID: WP_001298859.1
Location: 49943..50221 (279 bp)
Type: Others
Protein ID: Protein_53
Location: 50233..50718 (486 bp)
Type: Others
Protein ID: WP_000214415.1
Location: 50810..51628 (819 bp)
Type: Others
Protein ID: WP_001234753.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ECTO148_RS0021041328..42146+819WP_000779409.1lipoprotein NlpA-
ECTO148_RS0021542150..43073-924WP_000535950.1carboxylate/amino acid/amine transporter-
ECTO148_RS0022043251..43748-498WP_000509815.1hypothetical protein-
ECTO148_RS0022544341..45186-846WP_000065751.1DUF4942 domain-containing protein-
ECTO148_RS0023045242..45463-222WP_001296561.1DUF957 domain-containing protein-
ECTO148_RS0023545475..45963-489WP_000761714.1hypothetical protein-
ECTO148_RS0024045960..46337-378WP_001094448.1TA system toxin CbtA family proteinToxin
ECTO148_RS0024546427..46795-369WP_024175935.1type IV toxin-antitoxin system YeeU family antitoxinAntitoxin
ECTO148_RS0025046869..47090-222WP_000692346.1DUF987 domain-containing protein-
ECTO148_RS0025547159..47368-210Protein_50hypothetical protein-
ECTO148_RS0026047452..48198-747WP_001016257.1IS21-like element ISEc12 family helper ATPase IstB-
ECTO148_RS0026548213..49754-1542WP_001298859.1IS21-like element ISEc12 family transposase-
ECTO148_RS0027049943..50221-279Protein_53hypothetical protein-
ECTO148_RS0027550233..50718-486WP_000214415.1antirestriction protein-
ECTO148_RS0028050810..51628-819WP_001234753.1DUF945 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14221.22 Da        Isoelectric Point: 8.2919

>T292910 WP_001094448.1 NZ_LS992190:c46337-45960 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13598.40 Da        Isoelectric Point: 6.6255

>AT292910 WP_024175935.1 NZ_LS992190:c46795-46427 [Escherichia coli]
VSDTLSGTTHPDDNDDRLWWGLPCTVTPCFGARLVQKGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A376WVB1

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A3T7EC32

References