Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 36763..37406 Replicon plasmid 2
Accession NZ_LS992186
Organism Escherichia coli isolate Escherichia coli str. 3426

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag EC3426_RS24315 Protein ID WP_001044768.1
Coordinates 36990..37406 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag EC3426_RS24310 Protein ID WP_001261287.1
Coordinates 36763..36993 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC3426_RS24295 31941..33074 - 1134 WP_000545983.1 DUF3800 domain-containing protein -
EC3426_RS24300 33337..36456 - 3120 WP_001553851.1 hypothetical protein -
EC3426_RS24310 36763..36993 + 231 WP_001261287.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EC3426_RS24315 36990..37406 + 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
EC3426_RS24320 37568..39706 - 2139 WP_000350635.1 AAA family ATPase -
EC3426_RS24325 40250..40947 + 698 Protein_36 IS1 family transposase -
EC3426_RS24330 40984..41943 + 960 WP_133963875.1 nucleotidyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..164477 164477


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T292892 WP_001044768.1 NZ_LS992186:36990-37406 [Escherichia coli]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT292892 WP_001261287.1 NZ_LS992186:36763-36993 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References