Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4108273..4108927 Replicon chromosome
Accession NZ_LS992185
Organism Escherichia coli isolate Escherichia coli str. 3426

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag EC3426_RS20115 Protein ID WP_000244781.1
Coordinates 4108273..4108680 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag EC3426_RS20120 Protein ID WP_000354046.1
Coordinates 4108661..4108927 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC3426_RS20095 4104230..4105963 - 1734 WP_021523238.1 single-stranded-DNA-specific exonuclease RecJ -
EC3426_RS20100 4105969..4106679 - 711 WP_001521231.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EC3426_RS20105 4106704..4107600 - 897 WP_060581628.1 site-specific tyrosine recombinase XerD -
EC3426_RS20110 4107712..4108233 + 522 WP_001521233.1 flavodoxin FldB -
EC3426_RS20115 4108273..4108680 - 408 WP_000244781.1 protein YgfX Toxin
EC3426_RS20120 4108661..4108927 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
EC3426_RS20125 4109170..4110150 + 981 WP_000886050.1 tRNA-modifying protein YgfZ -
EC3426_RS20130 4110227..4110886 - 660 WP_000250269.1 hemolysin III family protein -
EC3426_RS20135 4111050..4111361 - 312 WP_001182949.1 N(4)-acetylcytidine aminohydrolase -
EC3426_RS20140 4111406..4112839 + 1434 WP_001521235.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T292888 WP_000244781.1 NZ_LS992185:c4108680-4108273 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT292888 WP_000354046.1 NZ_LS992185:c4108927-4108661 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References