Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3952569..3953152 Replicon chromosome
Accession NZ_LS992185
Organism Escherichia coli isolate Escherichia coli str. 3426

Toxin (Protein)


Gene name mazF Uniprot ID S1EZP4
Locus tag EC3426_RS19405 Protein ID WP_000254738.1
Coordinates 3952569..3952904 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S1P3W5
Locus tag EC3426_RS19410 Protein ID WP_000581937.1
Coordinates 3952904..3953152 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC3426_RS19390 3948456..3949754 - 1299 WP_000036723.1 phosphopyruvate hydratase -
EC3426_RS19395 3949841..3951478 - 1638 WP_000210878.1 CTP synthase (glutamine hydrolyzing) -
EC3426_RS19400 3951706..3952497 - 792 WP_001071643.1 nucleoside triphosphate pyrophosphohydrolase -
EC3426_RS19405 3952569..3952904 - 336 WP_000254738.1 endoribonuclease MazF Toxin
EC3426_RS19410 3952904..3953152 - 249 WP_000581937.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
EC3426_RS19415 3953230..3955464 - 2235 WP_000226798.1 GTP diphosphokinase -
EC3426_RS19420 3955512..3956813 - 1302 WP_001521172.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12098.04 Da        Isoelectric Point: 8.2618

>T292887 WP_000254738.1 NZ_LS992185:c3952904-3952569 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9355.74 Da        Isoelectric Point: 4.4665

>AT292887 WP_000581937.1 NZ_LS992185:c3953152-3952904 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1UB4
PDB 5CQX
PDB 5CK9
PDB 5CKH
PDB 5CO7
PDB 3NFC
PDB 5CR2
PDB 5CKB
PDB 5CQY
PDB 5CKD
PDB 5CKE
PDB 5CKF

Antitoxin

Source ID Structure
PDB 1UB4
PDB 5CQX
PDB 5CQY
PDB 1MVF
PDB 2MRN
PDB 2MRU
AlphaFold DB A0A7U9LMB4

References