Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4832791..4833407 Replicon chromosome
Accession NZ_LS992183
Organism Citrobacter freundii isolate Citrobacter freundii str. U2785

Toxin (Protein)


Gene name vapC Uniprot ID A0A0J1MQ96
Locus tag CFU2785_RS24130 Protein ID WP_003028682.1
Coordinates 4832791..4833165 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6B5NTK4
Locus tag CFU2785_RS24135 Protein ID WP_043018956.1
Coordinates 4833165..4833407 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFU2785_RS24115 4830294..4831196 + 903 WP_003028691.1 formate dehydrogenase O subunit beta -
CFU2785_RS24120 4831193..4831828 + 636 WP_003028686.1 formate dehydrogenase cytochrome b556 subunit -
CFU2785_RS24125 4831825..4832754 + 930 WP_003028685.1 formate dehydrogenase accessory protein FdhE -
CFU2785_RS24130 4832791..4833165 - 375 WP_003028682.1 type II toxin-antitoxin system VapC family toxin Toxin
CFU2785_RS24135 4833165..4833407 - 243 WP_043018956.1 ribbon-helix-helix domain-containing protein Antitoxin
CFU2785_RS24140 4833613..4834521 + 909 WP_003847901.1 alpha/beta hydrolase -
CFU2785_RS24150 4834672..4835613 - 942 WP_003825286.1 fatty acid biosynthesis protein FabY -
CFU2785_RS24155 4835658..4836095 - 438 WP_003028671.1 D-tyrosyl-tRNA(Tyr) deacylase -
CFU2785_RS24160 4836092..4836964 - 873 WP_003028669.1 virulence factor BrkB family protein -
CFU2785_RS24165 4836958..4837557 - 600 WP_003028663.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13674.89 Da        Isoelectric Point: 9.5622

>T292864 WP_003028682.1 NZ_LS992183:c4833165-4832791 [Citrobacter freundii]
MVKGSALFDTNILIDLFSGRNEAKLAIETWPPQNAISLITWMEVMVGAKKYHQEARTRVALGAFNVIGVSQDIAERSVSI
RQEYGMKLPDAIILATAQIHRLTLVTRNTKDFAGLSGVVTPYTL

Download         Length: 375 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9451.75 Da        Isoelectric Point: 4.3437

>AT292864 WP_043018956.1 NZ_LS992183:c4833407-4833165 [Citrobacter freundii]
MMAGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVEQYLERQDQAETTISRALGLWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MQ96

Antitoxin

Source ID Structure
AlphaFold DB A0A6B5NTK4

References