Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4479926..4480608 Replicon chromosome
Accession NZ_LS992183
Organism Citrobacter freundii isolate Citrobacter freundii str. U2785

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag CFU2785_RS22285 Protein ID WP_108168483.1
Coordinates 4480267..4480608 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag CFU2785_RS22280 Protein ID WP_108168484.1
Coordinates 4479926..4480246 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFU2785_RS22240 4475486..4476319 + 834 WP_108168491.1 DUF945 domain-containing protein -
CFU2785_RS22245 4476520..4477224 + 705 WP_108168490.1 WYL domain-containing protein -
CFU2785_RS22250 4477221..4477835 + 615 WP_108168489.1 hypothetical protein -
CFU2785_RS22255 4477921..4478331 + 411 WP_043082399.1 hypothetical protein -
CFU2785_RS22260 4478409..4478645 + 237 WP_108168488.1 DUF905 domain-containing protein -
CFU2785_RS22265 4478726..4479184 + 459 WP_108168487.1 antirestriction protein -
CFU2785_RS22270 4479200..4479676 + 477 WP_108168486.1 RadC family protein -
CFU2785_RS22275 4479686..4479907 + 222 WP_108168485.1 DUF987 domain-containing protein -
CFU2785_RS22280 4479926..4480246 + 321 WP_108168484.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CFU2785_RS22285 4480267..4480608 + 342 WP_108168483.1 TA system toxin CbtA family protein Toxin
CFU2785_RS22290 4480722..4481555 + 834 WP_099530882.1 DUF4942 domain-containing protein -
CFU2785_RS22295 4482047..4482673 + 627 WP_134216359.1 SLATT domain-containing protein -
CFU2785_RS22300 4482697..4483356 + 660 WP_134216360.1 RNA-directed DNA polymerase -
CFU2785_RS22305 4483403..4483930 + 528 WP_134216361.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4472337..4498708 26371


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(6-105)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12956.85 Da        Isoelectric Point: 7.2015

>T292861 WP_108168483.1 NZ_LS992183:4480267-4480608 [Citrobacter freundii]
MKPQPATTSRAAELYLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIQEHIDAGIMLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRQSRNNAVR

Download         Length: 342 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12027.71 Da        Isoelectric Point: 6.9370

>AT292861 WP_108168484.1 NZ_LS992183:4479926-4480246 [Citrobacter freundii]
MRSNITWGLQRDITPCMGARLVQEGNRLHYLADRASITGKFSDDECLKLDVVFPHFISRIESMLTTGELNPRHAHCITIY
HNGFTCEADTLGSCAYVYVVVYSTQR

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References